M
Malcolm R Ranson
Researcher at University of Manchester
Publications - 195
Citations - 15315
Malcolm R Ranson is an academic researcher from University of Manchester. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 57, co-authored 195 publications receiving 14150 citations. Previous affiliations of Malcolm R Ranson include Manchester Academic Health Science Centre & National Health Service.
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Journal ArticleDOI
Interstitial lung disease in lung cancer: Separating disease progression from treatment effects
TL;DR: Symptoms are vague, such as dyspnoea, cough and fever and can be difficult to differentiate from progressive disease, co-existing morbidity and new pulmonary pathology and diagnosis is by rigorous investigation to exclude all other differential diagnoses.
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Apoptosis pathway-targeted drugs—from the bench to the clinic
TL;DR: In this article, a selective review on the development of such drugs is provided, and issues regarding the regulation and design of early clinical trials of this type of molecularly targeted agent are discussed.
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Optimisation of circulating biomarkers of cell death for routine clinical use
Alastair Greystoke,Jeffrey Cummings,Timothy H Ward,Kathryn Simpson,Andrew G Renehan,Fouziah Butt,David J. Moore,Jourik A. Gietema,Fiona H Blackhall,Malcolm R Ranson,Anthony Hughes,Anthony Hughes,Caroline Dive +12 more
TL;DR: Recommendations that improve the reliability of M30 and M65 enzyme-linked immunosorbent assays for clinical use are presented and recommend serum as the preferred matrix with data more resistant to variations in collection.
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IAPs as a target for anticancer therapy.
TL;DR: This review will summarise the preclinical data for both ASO and small molecule inhibition of XIAP and discuss emerging Phase I data and future strategies for manipulation of XIap and the clinical development of XI AP inhibitors will be discussed.
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DNA methylation in circulating tumour DNA as a biomarker for cancer.
Ruth E Board,Lucy Knight,Alastair Greystoke,Fiona H Blackhall,Andrew Hughes,Caroline Dive,Malcolm R Ranson +6 more
TL;DR: This review will summarise the literature detailing DNA methylation in circulating tumour DNA and discuss some of the current controversies and technical challenges facing its use as a potential biomarker for cancer.