Carl C. Peck

TL;DR: Biomarker measurements provide an avenue for researchers to gain a mechanistic understanding of the differences in clinical response that may be influenced by uncontrolled variables (for example, drug metabolism).

TL;DR: Specific advances and contemporary challenges with respect to predicting the processes of drug clearance, distribution, and absorption are reviewed, together with the ability to anticipate the quantitative extent of PK-based drug-drug interactions and the impact of age, genetics, disease, and formulation.

TL;DR: The structural and stochastic components of trial simulation models are explained as a prelude to a listing of representative simulation projects, reflecting investigative applications of statistical methods, trial design comparisons, and full simulation of new drugs being developed.

TL;DR: In this article, the authors present a transdermal sampling system consisting of at least one sampler for retrieving and transferring analyte obtained transdermally from the skin of a subject; at least 1 detector system for identifying and quantifying said analyte; and at least logic module for relating the input data to other data obtained from the subject, displaying output information, and transmitting the output information to another system.

TL;DR: Clinical Pharmacology and Therapeutics (1992) 51, 465–473; doi:10.1038/clpt.1992.47