M
Malgorzata Topolewska
Researcher at Nencki Institute of Experimental Biology
Publications - 4
Citations - 27
Malgorzata Topolewska is an academic researcher from Nencki Institute of Experimental Biology. The author has contributed to research in topics: Exome sequencing & Limb-girdle muscular dystrophy. The author has an hindex of 2, co-authored 3 publications receiving 16 citations.
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Journal ArticleDOI
ANO5 mutations in the Polish limb girdle muscular dystrophy patients: Effects on the protein structure
Adam Jarmuła,Anna Łusakowska,Jakub Piotr Fichna,Malgorzata Topolewska,Anna Macias,Katherine Johnson,Ana Töpf,Volker Straub,Edyta Rosiak,Krzysztof Szczepaniak,Stanislaw Dunin-Horkawicz,Aleksandra Maruszak,Anna Kamińska,Maria Jolanta Redowicz +13 more
TL;DR: The presented data indicate that the identified ANO5 mutations contribute to the observed muscle pathology and broaden the genetic spectrum of LGMD myopathies.
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Formation of Aberrant Myotubes by Myoblasts Lacking Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion.
Lilya Lehka,Malgorzata Topolewska,Dominika Wojton,Olena Karatsai,Paloma Alvarez-Suarez,Paweł Pomorski,Maria Jolanta Redowicz +6 more
TL;DR: The data indicate that in the absence of MVI, the mechanisms controlling cytoskeleton organization, as well as myoblast adhesion and fusion, are dysregulated, leading to the formation of aberrant myotubes.
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Targeted Next-Generation Sequencing Reveals Mutations in Non-coding Regions and Potential Regulatory Sequences of Calpain-3 Gene in Polish Limb-Girdle Muscular Dystrophy Patients.
Anna Macias,Jakub Piotr Fichna,Malgorzata Topolewska,Maria J. Rȩdowicz,Anna Kamińska,Anna Kostera-Pruszczyk +5 more
TL;DR: In this paper, a targeted sequencing of the whole CAPN3 gene including not only intronic, 3' and 5' UTRs but also potential regulatory regions was performed in 27 patients suspected with LGMDR1.
Journal ArticleDOI
Loss of Unconventional Myosin VI Affects cAMP/PKA Signaling in Hindlimb Skeletal Muscle in an Age-Dependent Manner
L. V. Lehka,Dominika Wojton,Malgorzata Topolewska,V. V. Chumak,Łukasz Majewski,Maria Jolanta Redowicz +5 more
TL;DR: Observations indicate that lack of MVI impairs PKA signaling and results in the observed alterations in the SV muscle metabolism, in particular in newborn mice.