M
Malisetty V. Swamy
Researcher at University of Oklahoma
Publications - 20
Citations - 1543
Malisetty V. Swamy is an academic researcher from University of Oklahoma. The author has contributed to research in topics: Celecoxib & Azoxymethane. The author has an hindex of 14, co-authored 19 publications receiving 1495 citations. Previous affiliations of Malisetty V. Swamy include University of Oklahoma Health Sciences Center & National Institutes of Health.
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Journal ArticleDOI
Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency
Wei Dai,Qi Wang,Tongyi Liu,Malisetty V. Swamy,Yuqiang Fang,Suqing Xie,Radma Mahmood,Yang-Ming Yang,Ming Xu,Chinthalapally V. Rao +9 more
TL;DR: It is shown that BubR1+/− mouse embryonic fibroblasts are defective in spindle checkpoint activation, contain a significantly reduced amount of securin and Cdc20, and exhibit a greater level of micronuclei than do wild-type cells.
Journal Article
Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells
TL;DR: Results from the in vitro experiments indicated that diosgenin inhibits cell growth and induces apoptosis in the HT-29 human colon cancer cell line in a dose-dependent manner and seems to have potential as a novel colon cancer preventive agent.
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Colonic tumorigenesis in BubR1+/–ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
Chinthalapally V. Rao,Yang-Ming Yang,Malisetty V. Swamy,Tongyi Liu,Yuqiang Fang,Radma Mahmood,Meena Jhanwar-Uniyal,Wei Dai +7 more
TL;DR: It is suggested that BubR1 and Apc functionally interact in regulating metaphase-anaphase transition, deregulation of which may play a key role in genomic instability and development and progression of colorectal cancer.
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Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice.
Malisetty V. Swamy,Jagan M.R. Patlolla,Vernon E. Steele,Levy Kopelovich,Bandaru S. Reddy,Chinthalapally V. Rao +5 more
TL;DR: Observations show that atorvastatin inhibits intestinal tumorigenesis and that, importantly, when given together with low doses of celecoxib, it significantly increases the chemopreventive efficacy in an APC(min) mice.
Journal ArticleDOI
Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids.
Malisetty V. Swamy,Bhargava Citineni,Jagan M.R. Patlolla,Altaf Mohammed,Yuting Zhang,Chinthalapally V. Rao +5 more
TL;DR: Evidence is presented for the first time that curcumin combined with omega-3 fatty acids provide synergistic pancreatic tumor inhibitory properties.