M
Mamoru Nomura
Publications - 6
Citations - 363
Mamoru Nomura is an academic researcher. The author has contributed to research in topics: Irinotecan Hydrochloride & Histamine. The author has an hindex of 4, co-authored 6 publications receiving 347 citations.
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Inhibition of intestinal microflora β-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats
Kiyoshi Takasuna,Takehiro Hagiwara,Masaaki Hirohashi,Michiyuki Kato,Mamoru Nomura,Eiichi Nagai,Tsuyoshi Yokoi,Tetsuya Kamataki +7 more
TL;DR: SN-38, which results from the hydrolysis of SN-38 glucuronide by β-glucuronidase in the intestinal microflora, contributes considerably to the distribution of SN -38 in the large intestine tissue, and that inhibition of the β- glucuronodase activity by antibiotics results in decreased accumulation of SN
Journal ArticleDOI
Protective Effects of Kampo Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT-11), in Rats
Kiyoshi Takasuna,Yoshio Kasai,Yutaka Kitano,Kazuhiko Mori,Reiko Kobayashi,Takehiro Hagiwara,Kohji Kakihata,Masaaki Hirohashi,Mamoru Nomura,Eiichi Nagai,Tetsuya Kamataki +10 more
TL;DR: Results suggest that the prophylactic use of Kampo medicines (TJ‐14 and TJ‐114) may be of value against CPT‐11‐induced intestinal toxicity.
Journal ArticleDOI
Histological examination on Achilles tendon lesions induced by quinolone antibacterial agents in juvenile rats
TL;DR: The occurrence of the tendon lesions is different from that of the Achilles tendon disorders reported in older humans, but they are thought to be a useful model for them.
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Increasing-current electroshock seizure test: A new method for assessment of anti- and pro-convulsant activities of drugs in mice
TL;DR: The results indicate that the ICES test, like the maximal electroshock seizure test, is a model of grand mal-type seizure and is useful for evaluation of both the anti- and pro-convulsant activities of drugs.