Man Mohan Singh

TL;DR: Five compounds showed promising osteogenic activity, attributed to increased osteoblast proliferation, differentiation and mineralization as evidenced by marked increase in expression of alkaline phosphatase, an early phase differentiation marker, and alizarin Red S staining of osteoblasts cultured for 48 h and von Kossa silverStaining of nodules formed 15 days after culture with these compounds.

TL;DR: Early response of saponins to disrupt actin cytoskeleton in comparison with their effect on the nucleus suggests a membrane-mediated mode of action rather than via induction of apoptosis, demonstrating the potential of Sapindus sap onins for development as a microbicidal contraceptive for human use.

TL;DR: The study investigated spermicidal and antitrichomonas activities of selective serotonin reuptake inhibitor (SSRI) antidepressants with a view to generate new lead for development of dual-function s permicidal microbicides, which is an urgent global need.

TL;DR: The findings suggest the potential for developing products of this plant as contraceptives for human use and welfare and characterization of the agents responsible for body weight decrease and evaluation of their mechanism of action and safety profile might have added advantage for the management of obesity.

TL;DR: The antifertility activity of the ethanolic extract of D. binectariferum, its chloroform soluble fraction and rohitukine is demonstrated, demonstrating the absence of a basic side chain directed toward the antiestrogen binding site on the receptor appears to be responsible for the lack of any estrogen antagonistic activity.