Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Lead poisoning has been recognized as a major public health risk, particularly in developing countries. Though various occupational and public health measures have been undertaken in order to control lead exposure, cases of lead poisoning are still reported. Exposure to lead produces various deleterious effects on the hematopoietic, renal, reproductive and central nervous system, mainly through increased oxidative stress. These alterations play a prominent role in disease manifestations. Modulation of cellular thiols for protection against reactive oxygen species (ROS) has been used as a therapeutic strategy against lead poisoning. N-acetylcysteine, α-lipoic acid, vitamin E, quercetin and a few herbal extracts show prophylaxis against the majority of lead mediated injury in both in vitro and in vivo studies. This review provides a comprehensive account of recent updates describing health effects of lead exposure, relevant biomarkers and mechanisms involved in lead toxicity. It also updates the readers about recent advances in chelation therapy and newer therapeutic strategies, like nanoencapsulation, to treat lead induced toxic manifestations.

/pdf/toxicity-of-lead-a-review-with-recent-updates-2ym35em9ss.pdf

Toxicity of lead: A review with recent updates.

Donor-acceptor-substituted cyclopropane derivatives and their application in organic synthesis.

Low dose mercury toxicity and human health.

Mercury is a toxic heavy metal which is widely dispersed in nature. Most human exposure results from fish consumption or dental amalgam. Mercury occurs in several chemical forms, with complex pharmacokinetics. Mercury is capable of inducing a wide range of clinical presentations. Diagnosis of mercury toxicity can be challenging but can be obtained with reasonable reliability. Effective therapies for clinical toxicity have been described.

/pdf/mercury-toxicity-and-treatment-a-review-of-the-literature-17h00vn7vh.pdf

Mandava V. Rao

Papers

Protective effect of vitamin E against mercuric chloride reproductive toxicity in male mice.

Antioxidative potential of melatonin against mercury induced intoxication in spermatozoa in vitro

Role of ascorbic acid on mercuric chloride-induced genotoxicity in human blood cultures.

Protective role of melatonin against the mercury induced oxidative stress in the rat thyroid.

Curcumin supplementation protects from genotoxic effects of arsenic and fluoride.