M
Manman Guo
Researcher at University of Oxford
Publications - 25
Citations - 716
Manman Guo is an academic researcher from University of Oxford. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 9, co-authored 15 publications receiving 500 citations. Previous affiliations of Manman Guo include University of Dundee & Huazhong Agricultural University.
Papers
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Journal ArticleDOI
VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System
Francesca R. Cianfanelli,Juliana Alcoforado Diniz,Manman Guo,Virginia De Cesare,Matthias Trost,Sarah J. Coulthurst +5 more
TL;DR: This study defines an essential yet flexible role for PAAR proteins in the T6SS and highlights the existence of distinct versions of the machinery with differential effector specificity and efficiency of target cell delivery.
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Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system
Manman Guo,Hui Feng,Jun Zhang,Wenqin Wang,Yi Wang,Yuqing Li,Chunhui Gao,Huanchun Chen,Ying Feng,Zheng-Guo He +9 more
TL;DR: A new bacterial one-hybrid reporter vector system that provides a convenient and rapid strategy to determine the specific interaction between target DNA sequences and their transcription factors is developed and successfully determined the DNA-binding specificity of the transcription regulator Rv3133c to a previously reported promoter region of the gene Rv2031 in Mycobacterium tuberculosis.
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Proteomic Identification of Novel Secreted Antibacterial Toxins of the Serratia marcescens Type VI Secretion System
Maximilian J. Fritsch,Katharina Trunk,Juliana Alcoforado Diniz,Manman Guo,Matthias Trost,Sarah J. Coulthurst +5 more
TL;DR: This study has not only demonstrated that new and species-specific portfolios of antibacterial effectors are secreted by the T6SS, but also shown for the first time that PpkA-dependent post-translational regulation of the T 6SS is tailored to fit the needs of different bacterial species.
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Triggering MSR1 promotes JNK‐mediated inflammation in IL‐4‐activated macrophages
Manman Guo,Anetta Härtlova,Marek Gierlinski,Alan R. Prescott,Josep Castellví,Javier Hernández Losa,Sine Kragh Petersen,Ulf Alexander Wenzel,Brian D. Dill,Christoph H. Emmerich,Santiago Ramón y Cajal,David G. Russell,Matthias Trost,Matthias Trost +13 more
TL;DR: Proteomics identifies that MSR1 signals through JNK via K63 polyubiquitylation and provides evidence for the receptor's involvement in macrophage polarization and identifies the enhanced recruitment of the TAK1/MKK7/JNK signalling complex to phagosomes of IL‐4‐activated macrophages.
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High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow derived macrophages
TL;DR: An in‐depth proteomics characterization of phagosomes from RAW 264.7 and bone marrow derived macrophages is performed by quantifying more than 2500 phagosomal proteins and indicates that there are significant differences for a large number of proteins including important receptors such as mannose receptor 1 and Siglec‐1.