Manoel Nunes

TL;DR: An extensive in vivo analysis of patient-derived xenograft models for CRC shows the loss of human stroma cells after engraftment, observed a metastatic phenotype in some models, and compared the molecular profile with the drug sensitivity of each tumor model.

TL;DR: A large panel of PDX NSCLC models with a high frequency of mutations in EGFR, KRAS, NRAS, MEK1, BRAF, PTEN, and PI3KCA genes are established and with gene amplification of c‐MET and FGFR1 provide stable and reliable preclinical models for human lung cancer research.

TL;DR: In this article, the authors examined key molecular alterations of the IGF2-PI3K and ERBB-RAS pathways and response to cetuximab in colorectal cancer patients.

TL;DR: Encouraging preclinical data have prompted the initiation of IND-enabling studies with the goal to progress humAb-1-ADC to the clinic in patients with tumors expressing LAMP1 at the cell surface, and Characterization of a novel maytansinoid-antibody-drug conjugate targeting LAMP 1 expressed at the surface of tumor cells.

TL;DR: In this article, the authors proposed an in vitro method of selecting patients with cancer which comprises determining, in a biological sample of a patient with cancer, if said patient harbors a LAMP1 gene copy number gain; and selecting the patient based on the presence of LAMP 1 gene copy numbers gain.