M
Manuel Bravo
Researcher at University of California, San Francisco
Publications - 2
Citations - 1145
Manuel Bravo is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: HMG-CoA reductase & Tumor necrosis factor alpha. The author has an hindex of 2, co-authored 2 publications receiving 1109 citations.
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Journal ArticleDOI
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
Sawsan Youssef,Olaf Stüve,Juan C. Patarroyo,Pedro J. Ruiz,Pedro J. Ruiz,Jennifer L. Radosevich,Eun Mi Hur,Manuel Bravo,Dennis J. Mitchell,Raymond A. Sobel,Lawrence Steinman,Scott S. Zamvil +11 more
TL;DR: It is shown that oral atorvastatin prevented or reversed chronic and relapsing paralysis and has pleiotropic immunomodulatory effects involving both APC and T-cell compartments.
Journal ArticleDOI
Cutting Edge: Oral Type I IFN-τ Promotes a Th2 Bias and Enhances Suppression of Autoimmune Encephalomyelitis by Oral Glatiramer Acetate
Jeanne M. Soos,Olaf Stüve,Sawsan Youssef,Manuel Bravo,Howard M. Johnson,Howard L. Weiner,Scott S. Zamvil +6 more
TL;DR: When suboptimal doses were administered orally in combination to wild-type mice, IFN-τ and glatiramer acetate had a synergistic beneficial effect in suppression of EAE, and is a potential candidate for use as a single agent or in combination therapy for multiple sclerosis.