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Dennis J. Mitchell
Researcher at Stanford University
Publications - 51
Citations - 11934
Dennis J. Mitchell is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & Myelin basic protein. The author has an hindex of 39, co-authored 51 publications receiving 11607 citations. Previous affiliations of Dennis J. Mitchell include Juntendo University.
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Journal ArticleDOI
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
Paul A. Wender,Dennis J. Mitchell,Kanaka Pattabiraman,Erin T. Pelkey,Lawrence Steinman,Jonathan B. Rothbard +5 more
TL;DR: Overall, a transporter has been developed that is superior to Tat(49-57), protease resistant, and more readily and economically prepared and suggest that the guanidinium groups of Tat( 49-57) play a greater role in facilitating cellular uptake than either charge or backbone structure.
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Polyarginine enters cells more efficiently than other polycationic homopolymers.
TL;DR: It is demonstrated that the guanidine headgroup of arginine was the critical structural component responsible for the biological activity, indicating that the process was energy dependent, but did not involve endocytosis.
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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
Sawsan Youssef,Olaf Stüve,Juan C. Patarroyo,Pedro J. Ruiz,Pedro J. Ruiz,Jennifer L. Radosevich,Eun Mi Hur,Manuel Bravo,Dennis J. Mitchell,Raymond A. Sobel,Lawrence Steinman,Scott S. Zamvil +11 more
TL;DR: It is shown that oral atorvastatin prevented or reversed chronic and relapsing paralysis and has pleiotropic immunomodulatory effects involving both APC and T-cell compartments.
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Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
Hans Acha-Orbea,Dennis J. Mitchell,Luika Timmermann,David C. Wraith,Gilbert S. Tausch,Matthew K. Waldor,Scott S. Zamvil,Hugh O. McDevitt,Lawrence Steinman +8 more
TL;DR: Prevention and reversal of autoimmune disease with V beta 8-specific monoclonal antibodies was achieved in EAE because of a striking similarity in fine specificity of T cell receptors.
Journal ArticleDOI
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.
Dorothee Chabas,Sergio E. Baranzini,Dennis J. Mitchell,Claude C.A. Bernard,Susan R. Rittling,David T. Denhardt,Raymond A. Sobel,Christopher Lock,Marcela Karpuj,Marcela Karpuj,Rosetta Pedotti,Renu A. Heller,Jorge R. Oksenberg,Lawrence Steinman +13 more
TL;DR: Osteopontin appears to regulate T helper cell–1 (TH1)–mediated demyelinating disease, and it may offer a potential target in blocking development of progressive MS.