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Pedro J. Ruiz
Researcher at Stanford University
Publications - 34
Citations - 2733
Pedro J. Ruiz is an academic researcher from Stanford University. The author has contributed to research in topics: Antibody & Experimental autoimmune encephalomyelitis. The author has an hindex of 19, co-authored 34 publications receiving 2668 citations. Previous affiliations of Pedro J. Ruiz include California Pacific Medical Center & Weizmann Institute of Science.
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Journal ArticleDOI
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
Sawsan Youssef,Olaf Stüve,Juan C. Patarroyo,Pedro J. Ruiz,Pedro J. Ruiz,Jennifer L. Radosevich,Eun Mi Hur,Manuel Bravo,Dennis J. Mitchell,Raymond A. Sobel,Lawrence Steinman,Scott S. Zamvil +11 more
TL;DR: It is shown that oral atorvastatin prevented or reversed chronic and relapsing paralysis and has pleiotropic immunomodulatory effects involving both APC and T-cell compartments.
Journal ArticleDOI
Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity.
Ari Waisman,Pedro J. Ruiz,David L. Hirschberg,David L. Hirschberg,Avraham Gelman,Jorge R. Oksenberg,Stefan Brocke,Felix Mor,Irun R. Cohen,Lawrence Steinman,Lawrence Steinman +10 more
TL;DR: A novel feature of DNA immunization for autoimmune disease, reversal of the autoimmune response from Thl to Th2, may make this approach attractive for treatment of Thl–mediated diseases like multiple sclerosis, juvenile diabetes and rheumatoid arthritis.
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Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis.
William H. Robinson,Paulo Fontoura,Byung J. Lee,Henry E. Neuman de Vegvar,Henry E. Neuman de Vegvar,Jennifer Tom,Rosetta Pedotti,Carla DiGennaro,Dennis J. Mitchell,Derek A. Fong,Peggy P. Ho,Pedro J. Ruiz,Emanual Michael Maverakis,David B. Stevens,Claude C.A. Bernard,Roland Martin,Vijay K. Kuchroo,Johannes M. van Noort,Claude P. Genain,Sandra Amor,Tomas Olsson,Paul J. Utz,Hideki Garren,Lawrence Steinman +23 more
TL;DR: 'myelin proteome' microarrays are developed to profile the evolution of autoantibody responses in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), and tolerizing DNA vaccines encoding a greater number of array-determined myelin targets proved superior in treating established EAE and reduced epitope spreading of autoreactive B-cell responses.
Journal ArticleDOI
Combination of Gene Delivery and DNA Vaccination to Protect from and Reverse Th1 Autoimmune Disease via Deviation to the Th2 Pathway
Hideki Garren,Pedro J. Ruiz,Trent A. Watkins,Paulo Fontoura,Louis-Vu T. Nguyen,Einat R Estline,David L. Hirschberg,Lawrence Steinman +7 more
TL;DR: It is shown that DNA vaccines can be used to reverse established EAE by covaccination with the genes for myelin oligodendrocyte glycoprotein and IL-4 and this treatment strategy combines the antigen-specific effects of DNA vaccination and the beneficial effects of local gene delivery.
Journal Article
Suppressive Immunization with DNA Encoding a Self-Peptide Prevents Autoimmune Disease: Modulation of T Cell Costimulation
Pedro J. Ruiz,Hideki Garren,I. U. Ruiz,David L. Hirschberg,Louis-Vu T. Nguyen,Marcela Karpuj,M. T. Cooper,Dennis J. Mitchell,C G Fathman,Lawrence Steinman +9 more
TL;DR: A suppressive vaccination attenuates a prototypic autoimmune disease, experimental autoimmune encephalomyelitis, which presents clinically with paralysis, with DNA encoding a minigene for residues 139-151 of myelin proteolipid protein (PLP139-151), a pathogenic self-Ag.