M
Manuel F. Casanova
Researcher at University of South Carolina
Publications - 351
Citations - 14934
Manuel F. Casanova is an academic researcher from University of South Carolina. The author has contributed to research in topics: Autism & Autism spectrum disorder. The author has an hindex of 60, co-authored 343 publications receiving 13759 citations. Previous affiliations of Manuel F. Casanova include Johns Hopkins University & Veterans Health Administration.
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Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Minicolumnar pathology in autism.
TL;DR: Major differences between brains of autistic patients and controls in the number of minicolumns, in the horizontal spacing that separates cell columns, and in their internal structure are found.
Journal ArticleDOI
The minicolumn hypothesis in neuroscience
TL;DR: The minicolumn is a sophisticated local network that contains within it the elements for redundancy and plasticity and is a distinctive form of module that has evolved specifically in the neocortex.
Journal ArticleDOI
Minicolumnar abnormalities in autism
Manuel F. Casanova,Imke A. J. van Kooten,Imke A. J. van Kooten,Andrew E. Switala,Herman van Engeland,Helmut Heinsen,Harry W.M. Steinbusch,Patrick R. Hof,Juan Trippe,Janet Stone,Christoph Schmitz +10 more
TL;DR: This study corroborates the initial reports of a minicolumnopathy in autism within an independent sample and finds mean neuron and nucleolar cross sections were found to be smaller in autistic cases compared to controls, while neuron density in autism exceeded the comparison group by 23%.
Journal ArticleDOI
Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study.
Richard L. Suddath,Manuel F. Casanova,Terry E. Goldberg,David G. Daniel,John R. Kelsoe,Daniel R. Weinberger +5 more
TL;DR: In this article, the authors determined gray and white matter volumes in the temporal lobes and prefrontal regions of 17 patients with schizophrenia and 17 age and sex-matched normal subjects, and found that the volume of temporal lobe gray matter was 20% smaller in the patients than in the control subjects.