M
Manuel Torres
Researcher at University of the Balearic Islands
Publications - 30
Citations - 1501
Manuel Torres is an academic researcher from University of the Balearic Islands. The author has contributed to research in topics: Neurodegeneration & Docosahexaenoic acid. The author has an hindex of 15, co-authored 28 publications receiving 1333 citations. Previous affiliations of Manuel Torres include University of Seville & Netherlands Institute for Space Research.
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Journal ArticleDOI
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic
Sebastian Jimenez,David Baglietto-Vargas,Cristina Caballero,Ines Moreno-Gonzalez,Manuel Torres,Raquel Sanchez-Varo,Diego Ruano,Marisa Vizuete,Antonia Gutierrez,Javier Vitorica +9 more
TL;DR: Evidence is shown of a switch in the activated microglia phenotype from alternative, at the beginning of Aβ pathology, to a classical at advanced stage of the disease in this model, induced by the age-dependent accumulation of extracellular soluble Aβ oligomers.
Journal ArticleDOI
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
Raquel Sanchez-Varo,Laura Trujillo-Estrada,Elisabeth Sanchez-Mejias,Manuel Torres,Manuel Torres,David Baglietto-Vargas,Ines Moreno-Gonzalez,Vanessa De Castro,Sebastian Jimenez,Sebastian Jimenez,Diego Ruano,Diego Ruano,Marisa Vizuete,Marisa Vizuete,Jose Carlos Davila,José Manuel García-Verdugo,Antonio J. Jiménez,Javier Vitorica,Javier Vitorica,Antonia Gutierrez +19 more
TL;DR: These early abnormalities in axonal and presynaptic structures might represent the morphological substrate of hippocampal dysfunction preceding synaptic and neuronal loss and could significantly contribute to AD pathology in the preclinical stages.
Journal ArticleDOI
Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model *
Sebastian Jimenez,Manuel Torres,Manuel Torres,Marisa Vizuete,Marisa Vizuete,Raquel Sanchez-Varo,Elisabeth Sanchez-Mejias,Laura Trujillo-Estrada,Irene Carmona-Cuenca,Irene Carmona-Cuenca,Cristina Caballero,Cristina Caballero,Diego Ruano,Diego Ruano,Antonia Gutierrez,Javier Vitorica,Javier Vitorica +16 more
TL;DR: The age-dependent appearance of APP-derived soluble factors modulated the PI3K/Akt/GSK-3β signaling pathway through the major neurotrophin receptors and might provide insights into the selective vulnerability of specific neuronal groups in Alzheimer disease.
Journal ArticleDOI
Detection of the old stellar component of the major Galactic bar
P. L. Hammersley,Francisco Garzón,Francisco Garzón,T. J. Mahoney,Martin Lopez-Corredoira,Manuel Torres +5 more
TL;DR: In this article, the authors present near-infrared colour-magnitude diagrams and star counts for a number of regions along the Galactic plane, showing that along the l=27°, b=0° line of sight there is a feature at 5.7±0.7kpc with a density of stars at least a factor of 2 and probably more than a factor 5 times that of the disc at the same position.
Journal ArticleDOI
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
Manuel Torres,Manuel Torres,Sebastian Jimenez,Sebastian Jimenez,Raquel Sanchez-Varo,Victoria Navarro,Victoria Navarro,Laura Trujillo-Estrada,Elisabeth Sanchez-Mejias,Irene Carmona,Irene Carmona,Jose Carlos Davila,Marisa Vizuete,Marisa Vizuete,Antonia Gutierrez,Javier Vitorica,Javier Vitorica +16 more
TL;DR: A progressive age-dependent cytoskeletal pathology along with a reduction of lysosomal and, in minor extent, proteasomal activity could be directly implicated in the progressive accumulation of APP derived fragments (and Abeta peptides) in parallel with the increase of BACE-1 and gamma-secretase activities.