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Marisa Vizuete
Researcher at University of Seville
Publications - 46
Citations - 2814
Marisa Vizuete is an academic researcher from University of Seville. The author has contributed to research in topics: Microglia & Tyrosine hydroxylase. The author has an hindex of 25, co-authored 45 publications receiving 2436 citations. Previous affiliations of Marisa Vizuete include Spanish National Research Council & Paris Descartes University.
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Journal ArticleDOI
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic
Sebastian Jimenez,David Baglietto-Vargas,Cristina Caballero,Ines Moreno-Gonzalez,Manuel Torres,Raquel Sanchez-Varo,Diego Ruano,Marisa Vizuete,Antonia Gutierrez,Javier Vitorica +9 more
TL;DR: Evidence is shown of a switch in the activated microglia phenotype from alternative, at the beginning of Aβ pathology, to a classical at advanced stage of the disease in this model, induced by the age-dependent accumulation of extracellular soluble Aβ oligomers.
Journal ArticleDOI
Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema.
Marisa Vizuete,José L. Venero,Carmen Vargas,Anunciación A. Ilundáin,Miriam Echevarría,A. Machado,Josefina Cano +6 more
TL;DR: It is concluded that the induction of AQP4 mRNA expression is related to disruption of the blood-brain barrier and under brain edema conditions this water channel plays a key role in the reestablishment of the brain osmotic equilibrium.
Journal ArticleDOI
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
Raquel Sanchez-Varo,Laura Trujillo-Estrada,Elisabeth Sanchez-Mejias,Manuel Torres,Manuel Torres,David Baglietto-Vargas,Ines Moreno-Gonzalez,Vanessa De Castro,Sebastian Jimenez,Sebastian Jimenez,Diego Ruano,Diego Ruano,Marisa Vizuete,Marisa Vizuete,Jose Carlos Davila,José Manuel García-Verdugo,Antonio J. Jiménez,Javier Vitorica,Javier Vitorica,Antonia Gutierrez +19 more
TL;DR: These early abnormalities in axonal and presynaptic structures might represent the morphological substrate of hippocampal dysfunction preceding synaptic and neuronal loss and could significantly contribute to AD pathology in the preclinical stages.
Journal ArticleDOI
Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model *
Sebastian Jimenez,Manuel Torres,Manuel Torres,Marisa Vizuete,Marisa Vizuete,Raquel Sanchez-Varo,Elisabeth Sanchez-Mejias,Laura Trujillo-Estrada,Irene Carmona-Cuenca,Irene Carmona-Cuenca,Cristina Caballero,Cristina Caballero,Diego Ruano,Diego Ruano,Antonia Gutierrez,Javier Vitorica,Javier Vitorica +16 more
TL;DR: The age-dependent appearance of APP-derived soluble factors modulated the PI3K/Akt/GSK-3β signaling pathway through the major neurotrophin receptors and might provide insights into the selective vulnerability of specific neuronal groups in Alzheimer disease.
Journal ArticleDOI
Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
Victoria Navarro,Victoria Navarro,Elisabeth Sanchez-Mejias,Sebastian Jimenez,Sebastian Jimenez,Clara Muñoz-Castro,Clara Muñoz-Castro,Raquel Sanchez-Varo,Jose Carlos Davila,Marisa Vizuete,Marisa Vizuete,Antonia Gutierrez,Javier Vitorica,Javier Vitorica +13 more
TL;DR: Comparing the microglial response between amyloidogenic transgenic models, such as APP/PS1 and AD patients and patients with Alzheimer’s disease is highlighted.