Manuela Teresa Raimondi

TL;DR: The concept of “force isotropy” relevant to cytoskeletal forces and relevant to extracellular loads acting on cells is introduced, to provide an interpretation of how the effects of insoluble biophysical signals can be used to direct stem cells fate in vitro.

TL;DR: TiN-coated titanium alloy femoral heads are inadequate in the task of resisting third body wear mechanisms in vivo according to the results of the study performed on four titanium nitride (TiN) coated prosthetic femoral Heads collected at revision surgery together with patient data.

TL;DR: A computational model of culture medium flow through the microstructure of a porous scaffold, during direct- perfused culture is developed to quantify the effects of fluid-dynamic shear on the growth modulation of tissue-engineered cartilage constructs, to potentially enhance tissue growth in vitro.

TL;DR: An easily customizable 3D model is described, in which the tumor microenvironment conditions are modulated and the functionality of different T cell preparations is tested, and the microdevice platform enables us to decipher the factors that can alter T cell function in 3D and can serve as a preclinical assay to tailor the most efficient immunotherapy configuration for a specific therapeutic goal.

TL;DR: A CFD model of the flow of culture medium through a 3D scaffold of homogeneous geometry is developed, with the aim of predicting the shear stress acting on cells as a function of parameters that can be controlled during the scaffold fabrication process, and during the cell culture, such as the medium flow rate and the diameter of the perfused scaffold section.