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Anthony T. Tan
Researcher at National University of Singapore
Publications - 73
Citations - 6743
Anthony T. Tan is an academic researcher from National University of Singapore. The author has contributed to research in topics: T cell & Hepatitis B virus. The author has an hindex of 29, co-authored 61 publications receiving 3763 citations. Previous affiliations of Anthony T. Tan include Agency for Science, Technology and Research.
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Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
Journal ArticleDOI
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Anthony T. Tan,Martin Linster,Chee Wah Tan,Nina Le Bert,Wan Ni Chia,Kamini Kunasegaran,Yan Zhuang,Christine Y.L. Tham,Adeline Chia,Gavin J. D. Smith,Barnaby Edward Young,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,David C. Lye,Lin-Fa Wang,Antonio Bertoletti,Antonio Bertoletti +18 more
TL;DR: In this article, the authors quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T-cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins.
Journal ArticleDOI
Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.
Oi Wing Ng,Adeline Chia,Anthony T. Tan,Ramesh Jadi,Hoe Nam Leong,Antonio Bertoletti,Yee-Joo Tan +6 more
TL;DR: The knowledge of the persistence of Sars-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable.
Journal ArticleDOI
IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells
Xin-Zi Tang,Juandy Jo,Anthony T. Tan,Elena Sandalova,Adeline Chia,K.C. Tan,Kang Hoe Lee,Adam J. Gehring,Gennaro De Libero,Gennaro De Libero,Antonio Bertoletti +10 more
TL;DR: Analysis of MAIT cells resident in the vascular bed of livers showed that they represented the majority of T cells expressing NK markers and the dominant IL-17A+ T cell subset in the human liver sinusoids, and it was shown that IL-7, a cytokine produced by hepatocytes during inflammation, regulated TCR-mediated activation ofMAIT cells, licensing them to dramatically increase Th1 cytokines and IL- 17A production.
Journal ArticleDOI
A Dynamic Immune Response Shapes COVID-19 Progression.
Eugenia Z. Ong,Yvonne Fu Zi Chan,Wan Ying Leong,Natalie Mei Ying Lee,Shirin Kalimuddin,Shirin Kalimuddin,Salahudeen Mohamed Haja Mohideen,Kian Sing Chan,Anthony T. Tan,Antonio Bertoletti,Eng Eong Ooi,Eng Eong Ooi,Jenny G. Low,Jenny G. Low +13 more
TL;DR: In this article, the authors conducted daily transcriptomic profiling of three COVID-19 cases and found that the early immune response in SARS-coronavirus-2 (SARS-CoV2) infection is highly dynamic.