Prospective Cohort Study

Background: This Guideline, a collaborative effort from the American Thoracic Society, Society of Thoracic Surgeons, and Society of Thoracic Radiology, aims to provide evidence-based recommendation...

https://www.atsjournals.org/doi/pdf/10.1164/rccm.201807-1415ST

Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline.

Ultrasmall inorganic nanoparticles: State-of-the-art and perspectives for biomedical applications.

Recently, much attention has been given to the development of biofunctionalized nanoparticles with magnetic properties for novel biomedical imaging. Guided, smart, targeting nanoparticulate magneti ...

Synthesis and characterization of PEGylated Gd2O3 nanoparticles for MRI contrast enhancement.

The main characteristics of aqueous dispersions of nanoparticles are considered. One of the results of the work is the synthesis of calcium zirconate nanoparticles. The particles were obtained by the solution combustion method and analyzed by X-ray diffraction and X-ray fluorescence methods. The next step is to preparation of aqueous dispersion based on the synthesized nanoparticles, conducts studies on their stability, and carried out experiments to study the process of dispersion boiling. As a result, a conclusion has been made about a promising method of fixing nanoparticles on the heating surface. The obtained results showed that the heat exchange efficiency at the flat vertical heater is depended on exposure in the bubble boiling regime. The choice of nanoparticles and their concentration also have a significant influence at the discovered effect.

Санкт-Петербургский государственный университет культуры и искусств

US Hospitalizations for Malignant Pleural Effusions: Data From the 2012 National Inpatient Sample

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established first-line invasive modality for mediastinal lymph node staging in lung cancer patients and in the diagnostic workup of patients with mediastinal adenopathy With the current 21- and 22-gauge (G) EBUS-TBNA needles, the procedure can be limited by the degree of flexibility in the needle and the size of the lumen in tissue acquisition Objective: We report our initial experience with a first-generation flexible 19-G EBUS-TBNA (Flex 19G; Olympus Respiratory America, Redmond, WA, USA) needle with regards to efficacy and safety Methods: The Flex 19G EBUS-TBNA needle was used in 47 selected patients with enlarged hilar and/or mediastinal lymphadenopathy at 3 centers The standard Olympus EBUS scope with a 22-mm working channel was used in all cases Results: The diagnostic yield of the Flex 19G needle according to clinical cytopathology reports was 89% (42/47) The diagnosis and their respective diagnostic yield with the Flex 19G EBUS-TBNA needle were malignancy 24/27 (89%), sarcoidosis 13/14 (93%), and reactive lymph node hyperplasia 5/6 (83%) The mean short axis of the sampled lymph nodes was 19 ± 9 mm No complications occurred except for 1 instance of moderate bleeding, which did not require intervention beyond suctioning and subsequently resolved All 13 patients diagnosed with adenocarcinoma by the 19-G needle had sufficient tissue for genetic testing Conclusion: EBUS-TBNA using the first-generation Flex 19G needle is feasible and safe with promising diagnostic yield while providing a greater degree of flexion with the Olympus EBUS scope Additional clinical evaluations are warranted

/pdf/flexible-19-gauge-endobronchial-ultrasound-guided-j8gd9mxdmq.pdf

Flexible 19-Gauge Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Needle: First Experience

Synthesis of very small (about 4?nm) perovskite structured gadolinium orthoferrite nanoparticles (GdFeO3) was performed by the polyol method. The material shows promising relaxivity properties and potential as a contrast agent in magnetic resonance imaging. The perovskite nanoparticles were characterized by x-ray diffraction, transmission electron microscopy, energy dispersive x-ray spectroscopy, Fourier transform infrared spectroscopy, magnetic resonance, and magnetization measurements. Upon heating in air at 800??C for 3?h the size of the crystals increased to about 40?nm. The crystalline structure of the heat treated compound is in good agreement with perovskite GdFeO3 as the primary product. Contributions from various secondary phases were also identified, including one hitherto unknown phase with the suggested composition 'Gd3FeO6' and isostructural with Gd3GaO6. The novel 'Gd3FeO6' phase appears to be kinetically stabilized in the nano state.

https://iopscience.iop.org/article/10.1088/0957-4484/19/8/085608/pdf

Colloidal synthesis and characterization of ultrasmall perovskite GdFeO3 nanocrystals

Background: The use of self-expandable metallic stents (SEMS) in benign airway disease was the object of a boxed warning from the United States Food and Drug Administration in 2005 due to the risk of stent-related complications and difficulties associated with their removal. Third-generation fully covered SEMS have been commercialized since this warning and theoretically should not present the same difficulties associated with removal as they cannot become embedded in the airway mucosa. Objectives: We aimed to examine the safety and efficacy of a specific third-generation SEMS, the Silmet stent. Methods: We reviewed the records of all patients treated for benign airway stenosis with third-generation Silmet SEMS from January 2011 to December 2015 at the North Hospital of Marseilles, France. Results: Forty SEMS were inserted in 30 patients over this period. Twenty (50.0%) stents were removed because of stent-related complications after a median of 77.0 ± 96.6 days (migration 32.5%, granulation tissue formation 7.5%, subjective intolerance 5.0%, mucus plugging 2.5%, laryngeal edema 2.5%). There were no cases of stent-related mortality. All complications were managed successfully endoscopically. Thirty-six stents (90.0%) were removed successfully after a median of 122.0 ± 113.2 days without any complications. The clinical success rate of stent treatment was 40.7%. Conclusion: Third-generation SEMS are a safe treatment option for complex benign airway stenosis, but complications requiring stent removal are frequent. Further studies are needed to compare the performance of third-generation SEMS and silicone stents in benign airway stenosis.

/pdf/safety-and-efficacy-of-a-fully-covered-self-expandable-53ci18bvwz.pdf

Safety and Efficacy of a Fully Covered Self-Expandable Metallic Stent in Benign Airway Stenosis

Hemoptysis is a frequent manifestation of a wide variety of diseases, with mild to life-threatening presentations. The diagnostic workup and the management of severe hemoptysis are often challenging. Advances in endoscopic techniques have led to different new therapeutic approaches. Cold saline, vasoconstrictive and antifibrinolytic agents, oxidized regenerated cellulose, biocompatible glue, laser photocoagulation, argon plasma coagulation, and endobronchial stents and valves are amongst the tools available to the bronchoscopist. In this article, we review the evidence regarding the definition, etiology, diagnostic modalities, and treatment of severe hemoptysis in the modern era with emphasis on bronchoscopic techniques.

/pdf/approach-to-hemoptysis-in-the-modern-era-6icf0j3c8g.pdf

Marc Fortin

Papers

US Hospitalizations for Malignant Pleural Effusions: Data From the 2012 National Inpatient Sample

Flexible 19-Gauge Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Needle: First Experience

Colloidal synthesis and characterization of ultrasmall perovskite GdFeO3 nanocrystals

Safety and Efficacy of a Fully Covered Self-Expandable Metallic Stent in Benign Airway Stenosis

Approach to Hemoptysis in the Modern Era.