M
Marc L. Mendillo
Researcher at Northwestern University
Publications - 43
Citations - 3218
Marc L. Mendillo is an academic researcher from Northwestern University. The author has contributed to research in topics: MutS-1 & HSF1. The author has an hindex of 23, co-authored 36 publications receiving 2640 citations. Previous affiliations of Marc L. Mendillo include Massachusetts Institute of Technology & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers
Marc L. Mendillo,Sandro Santagata,Sandro Santagata,Martina Koeva,George W. Bell,Rong Hu,Rong Hu,Rulla M. Tamimi,Rulla M. Tamimi,Ernest Fraenkel,Tan A. Ince,Luke Whitesell,Susan Lindquist +12 more
TL;DR: In this paper, the authors identify an HSF1-regulated transcriptional program specific to highly malignant cells and distinct from heat shock, which supports oncogenic processes: cell-cycle regulation, signaling, metabolism, adhesion and translation.
Journal ArticleDOI
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer
Sandro Santagata,Rong Hu,Nan Lin,Marc L. Mendillo,Laura C. Collins,Susan E. Hankinson,Stuart J. Schnitt,Luke Whitesell,Rulla M. Tamimi,Susan Lindquist,Tan A. Ince +10 more
TL;DR: It is concluded that increased HSF1 is associated with reduced breast cancer survival and should be evaluated prospectively as an independent prognostic indicator in ER-positive breast cancer.
Journal ArticleDOI
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
Ruth Scherz-Shouval,Sandro Santagata,Sandro Santagata,Sandro Santagata,Marc L. Mendillo,Lynette M. Sholl,Irit Ben-Aharon,Irit Ben-Aharon,Andrew H. Beck,Dora Dias-Santagata,Martina Koeva,Salomon M. Stemmer,Salomon M. Stemmer,Luke Whitesell,Susan Lindquist,Susan Lindquist +15 more
TL;DR: It is reported that the transcriptional regulator heat shock factor 1 (HSF1) is frequently activated in cancer-associated fibroblasts (CAFs), where it is a potent enabler of malignancy.
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
Ruth Scherz-Shouval,Sandro Santagata,Marc L. Mendillo,Lynette M. Sholl,Irit Ben-Aharon,Andrew H. Beck,Dora Dias-Santagata,Salomon M. Stemmer,Luke Whitesell,Martina Koeva,Susan Lindquist +10 more
TL;DR: In this article, the authors report that the transcriptional regulator heat shock factor 1 (HSF1) is frequently activated in cancer-associated fibroblasts (CAFs), where it is a potent enabler of malignancy.
Journal ArticleDOI
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.
Sandro Santagata,Marc L. Mendillo,Yun-Chi Tang,Yun-Chi Tang,Aravind Subramanian,Casey C. Perley,Stéphane P. Roche,Bang Wong,Rajiv Narayan,Hyoungtae Kwon,Martina Koeva,Angelika Amon,Angelika Amon,Todd R. Golub,John A. Porco,Luke Whitesell,Susan Lindquist +16 more
TL;DR: The ribosome functions as a central information hub in malignant cells: Translational flux conveys information about the cell’s metabolic status to regulate the transcriptional programs that support it, and multiple unbiased chemical and genetic approaches establish HSF1 as a prime transducer of this information.