Marc Schumacher

TL;DR: A review of the current knowledge about the cellular action of lycopene and the molecular targets responsible for its remarkable chemopreventive and anti-proliferative activity provides evidence for the biological activity of some oxidized Lycopene metabolites, which seem to be partially responsible for the strong and manifold anti-cancer potential of lyCopene.

TL;DR: A novel structural class of phenazine derivatives, the dermacozines, which exhibited moderate cytotoxic activity against leukaemia cell line K562 with IC(50) values of 9 and 7 microM, respectively, while the highest radical scavenger activity was observed for der Macozine C (3) with an IC( 50) value of 8.4 microM.

TL;DR: This work focuses here on selected marine compounds that act on the six hallmarks of cancer presented namely self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replication, sustained angiogenesis and tissue invasion and metastasis.

TL;DR: A series of 18 heterocyclic cyclohexanone analogues of curcumin have been synthesised and screened for their activity in both adherent and non-adherent cancer cell models and the lead drug candidate, B10, showed potent cytotoxicity towards MBA-MB-231 breast cancer cells.

TL;DR: The role of West African traditional pharmacopeia in cancer treatment as well as medicinal plants with anti-cancer properties are reviewed.