M
Marc Schumacher
Researcher at University of Aberdeen
Publications - 27
Citations - 1483
Marc Schumacher is an academic researcher from University of Aberdeen. The author has contributed to research in topics: K562 cells & Cancer cell. The author has an hindex of 20, co-authored 27 publications receiving 1277 citations.
Papers
More filters
Journal ArticleDOI
Antioxidant and anti-proliferative properties of lycopene
TL;DR: A review of the current knowledge about the cellular action of lycopene and the molecular targets responsible for its remarkable chemopreventive and anti-proliferative activity provides evidence for the biological activity of some oxidized Lycopene metabolites, which seem to be partially responsible for the strong and manifold anti-cancer potential of lyCopene.
Journal ArticleDOI
Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment
Wael M. Abdel-Mageed,Wael M. Abdel-Mageed,Bruce F. Milne,Marcell Wagner,Marc Schumacher,Peter Sandor,Wasu Pathom-aree,Michael Goodfellow,Alan T. Bull,Koki Horikoshi,Rainer Ebel,Marc Diederich,Hans-Peter Fiedler,Marcel Jaspars +13 more
TL;DR: A novel structural class of phenazine derivatives, the dermacozines, which exhibited moderate cytotoxic activity against leukaemia cell line K562 with IC(50) values of 9 and 7 microM, respectively, while the highest radical scavenger activity was observed for der Macozine C (3) with an IC( 50) value of 8.4 microM.
Journal ArticleDOI
Gold from the sea: marine compounds as inhibitors of the hallmarks of cancer.
TL;DR: This work focuses here on selected marine compounds that act on the six hallmarks of cancer presented namely self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replication, sustained angiogenesis and tissue invasion and metastasis.
Journal ArticleDOI
Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin.
Babasaheb Yadav,Sebastien Taurin,Rhonda J. Rosengren,Marc Schumacher,Marc Diederich,Tiffany J. Somers-Edgar,Lesley Larsen +6 more
TL;DR: A series of 18 heterocyclic cyclohexanone analogues of curcumin have been synthesised and screened for their activity in both adherent and non-adherent cancer cell models and the lead drug candidate, B10, showed potent cytotoxicity towards MBA-MB-231 breast cancer cells.
Journal ArticleDOI
Traditional West African pharmacopeia, plants and derived compounds for cancer therapy.
TL;DR: The role of West African traditional pharmacopeia in cancer treatment as well as medicinal plants with anti-cancer properties are reviewed.