Márcia Aparecida Antônio

TL;DR: For all evaluated cell lines, monastrol was shown to be more active than its oxo-analogue, except for HT-29 cell line, suggesting the importance of the sulfur atom for the antiproliferative activity.

TL;DR: Results suggest that both CHE and coumarin may influence the secretion control mediated by the parasympathetic system.

TL;DR: The total syntheses of (R)-goniothalamin, a styryl lactone isolated from several Goniothalamus species, via catalytic asymmetric allylation of alpha-benzyloxyacetaldehyde followed by ring-closing metathesis and Wittig olefination are reported.

TL;DR: Blocking free sulfhydryl groups by in vivo N-ethylmaleimide alkylation caused an increase in mucosal ulcerative lesions, suggesting the importance of sulfHydryl compounds in the gastric mucosa protection.

TL;DR: Three compounds isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, suggesting that the antiulkerogenic activity is a consequence of prostaglandin synthesis increase.