Marcin Cieślak

TL;DR: The human plasma 3' -exonuclease responsible for the degradation of PS-oligos is identified as a soluble form of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) (EC 3.4.1.1/EC3.6.1), and it is shown that adenosine or deoxyadenosine (alpha-thio)triphosphates can act as potent inhibitors of NPPs.

TL;DR: The supramolecular interactions can provide a favourable tool to construct a drug delivery system with controlled drug release and efficient tumor cell suppression which is beneficial for cancer therapy.

TL;DR: In silico and in vitro data suggested that this new group of compounds might be considered as a promising scaffold for further modification of more potent and selective anticancer and immunomodulatory agents.

TL;DR: Five compounds showed significant cytotoxic activity against all tested cell lines and selectivity for cancer cell lines, and the presence of bromine introduced to a methyl or acetyl group that was attached to the benzofuran system increased their cytotoxicity both in normal and cancer cells.

TL;DR: The results suggested a selective immunosuppressive activity, non-typical for mushroom derived polysaccharides, in the form of inhibition of human T lymphocyte proliferation induced by mitogens and protection of cells from oxidative stress conditions.