W
Wojciech J. Stec
Researcher at Polish Academy of Sciences
Publications - 363
Citations - 7827
Wojciech J. Stec is an academic researcher from Polish Academy of Sciences. The author has contributed to research in topics: Nucleoside & Oligonucleotide. The author has an hindex of 44, co-authored 363 publications receiving 7494 citations. Previous affiliations of Wojciech J. Stec include Johns Hopkins University School of Medicine & General Atomics.
Papers
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Inner-orbital binding-energy shifts of antimony and bismuth compounds
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Inner-orbital photoelectron spectroscopy of the alkali metal halides, perchlorates, phosphates, and pyrophosphates
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Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogs of oligodeoxyribonucleotides
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Design, Synthesis, and Antiviral Activity of 2‘-Deoxy-2‘-fluoro-2‘-C-methylcytidine, a Potent Inhibitor of Hepatitis C Virus Replication
Jeremy L. Clark,Laurent Hollecker,J. Christian Mason,Lieven J. Stuyver,Phillip M. Tharnish,Stefania Lostia,Tamara R. McBrayer,Raymond F. Schinazi,Kyoichi A. Watanabe,Michael J. Otto,Furman Phillip,Wojciech J. Stec,Steven E. Patterson,Krzysztof W. Pankiewicz +13 more
TL;DR: 2'-C-methylcytidine and 2-fluoro-2-methyl-3,5-di-O-benzoyl-beta-d-ribofuranosyl were found to be potent and selective inhibitors of HCV replication in a subgenomic HCV replicon assay system.
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Competitive cAMP antagonists for cAMP-receptor proteins.
P. J. M. Van Haastert,R. van Driel,Bernd Jastorff,Janina Baraniak,Wojciech J. Stec,R J De Wit +5 more
TL;DR: In this article, two diastereoisomers are known for each derivative: (SP)-cAMPPS, (RP)-cAMPS, and (SP-cAMPN(CH3)2, with apparent inhibition constants between 0.8 and 8 microM.