Marco Augustin

TL;DR: This study establishes an open resource for dissecting DNA methylation heterogeneity in a genetically diverse and heterogeneous cancer, and demonstrates the feasibility of integrating epigenomics, radiology, and digital pathology for a national cohort, thereby leveraging existing samples and data collected as part of routine clinical practice.

TL;DR: The improved transverse resolution and the reduced depth of focus of AO-OCT and AO -OCTA greatly reduce shadowing artifacts allowing for a better differentiation and segmentation of different vasculature layers of the inner retina.

TL;DR: By performing a spectroscopic analysis of the OCM data, differences in the characteristics for WM, GM, and neuritic amyloid-beta plaques were found.

TL;DR: It is shown that melanin pigmentation in the RPE and choroid can be quantified via depolarization imaging and therefore PS-OCT is a useful tool for the noninvasive quantitative assessment of pigmentary changes in vision-threatening diseases such as age-related macular degeneration.

TL;DR: Evidence is provided that PS-OCM is able to assess amyloidosis based on intrinsic birefringent properties as well as the 3D structure of senile Aβ plaques based on computationally modelled for different illumination settings and plaque sizes.