M
Marco Bolis
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 46
Citations - 791
Marco Bolis is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Medicine & Retinoic acid. The author has an hindex of 13, co-authored 32 publications receiving 548 citations. Previous affiliations of Marco Bolis include Swiss Institute of Bioinformatics & University of Lugano.
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Journal ArticleDOI
Retinoids and breast cancer: from basic studies to the clinic and back again.
Enrico Garattini,Marco Bolis,Silvio Garattini,Maddalena Fratelli,Floriana Centritto,Gabriela Paroni,Maurizio Gianni,Adriana Zanetti,Anna Pagani,James N. Fisher,Alberto Zambelli,Mineko Terao +11 more
TL;DR: The basic knowledge acquired on the anti-tumor activity of classic retinoids, like ATRA, in mammary tumors, is reviewed, focusing on the underlying cellular and molecular mechanisms and the determinants of retinoid sensitivity/resistance.
Journal ArticleDOI
Structure and function of mammalian aldehyde oxidases
Mineko Terao,Maria João Romão,Silke Leimkühler,Marco Bolis,Maddalena Fratelli,Catarina Coelho,Teresa Santos-Silva,Enrico Garattini +7 more
TL;DR: An overview and a discussion of the current knowledge on mammalian AOX isoenzymes are provided.
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Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression
Mami Kurosaki,Marco Bolis,Maddalena Fratelli,Maria Monica Barzago,Linda Pattini,Gemma Perretta,Mineko Terao,Enrico Garattini +7 more
TL;DR: This work cloned the cDNAs encoding the AOX proteins of guinea pig and cynomolgus monkeys, two unique species as to the evolution of this enzyme family, and identifies chimeric RNAs from the human AOX3 and AOx3L1 pseudogenes with potential to encode a novel microRNA.
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Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
Floriana Centritto,Gabriela Paroni,Marco Bolis,Silvio Garattini,Mami Kurosaki,Maria Monica Barzago,Adriana Zanetti,James N. Fisher,Mark Francis Scott,Linda Pattini,Monica Lupi,Paolo Ubezio,Francesca Piccotti,Alberto Zambelli,Paola Rizzo,Maurizio Gianni,Maddalena Fratelli,Mineko Terao,Enrico Garattini +18 more
TL;DR: Gen sets of predictive potential which are associated with ATRA sensitivity in breast cancer cell lines are defined and validated in short‐term tissue cultures of Luminal/ER+ and triple‐negative tumors and perturbations in the transcriptomic profiles afforded by ATRA are determined.
Journal ArticleDOI
BET proteins regulate homologous recombination-mediated DNA repair: BRCAness and implications for cancer therapy.
Catia Mio,Lorenzo Gerratana,Marco Bolis,Federica Caponnetto,Andrea Zanello,Mattia Barbina,Carla Di Loreto,Enrico Garattini,Giuseppe Damante,Fabio Puglisi +9 more
TL;DR: The aim of this study was to assess BRD4 regulation in homologous recombination‐mediated DNA repair and to explore novel clinical strategies through the combinations of the pharmacological induction of epigenetic BRCAness in BRC a1 wild‐type triple negative breast cancer cells by means of BET inhibitors and compounds already available in clinic.