M
Marcus Gutscher
Researcher at German Cancer Research Center
Publications - 3
Citations - 1248
Marcus Gutscher is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Target protein & RoGFP. The author has an hindex of 3, co-authored 3 publications receiving 1079 citations.
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Journal ArticleDOI
Real-time imaging of the intracellular glutathione redox potential.
Marcus Gutscher,Anne Laure Pauleau,Laurent Marty,Thorsten Brach,Guido H. Wabnitz,Yvonne Samstag,Andreas J. Meyer,Tobias P. Dick +7 more
TL;DR: It is demonstrated that the fusion of human glutaredoxin-1 to roGFP2 facilitates specific real-time equilibration between the sensor protein and the glutathione redox couple, which facilitated the observation of redox changes associated with growth factor availability, cell density, mitochondrial depolarization, respiratory burst activity and immune receptor stimulation.
Journal ArticleDOI
Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases *♦
Marcus Gutscher,Mirko C. Sobotta,Guido H. Wabnitz,Seda Ballikaya,Andreas J. Meyer,Yvonne Samstag,Tobias P. Dick +6 more
TL;DR: The concept that certain peroxidases harbor an intrinsic and powerful capacity to act as H2O2-dependent protein thiol oxidases when they are recruited into proximity of oxidizable target proteins is supported.
Journal ArticleDOI
Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1.
Ulla Schwertassek,Yves Balmer,Marcus Gutscher,Lars Weingarten,Marc Preuss,Johanna Engelhard,Monique Winkler,Tobias P. Dick +7 more
TL;DR: In this article, a mechanism-based kinetic trapping technique was used to identify disulfide exchange interactions on the intact surface of living lymphocytes, finding that Trx1 catalytically interacts with a single principal target protein.