Tobias P. Dick

TL;DR: It is demonstrated that the fusion of human glutaredoxin-1 to roGFP2 facilitates specific real-time equilibration between the sensor protein and the glutathione redox couple, which facilitated the observation of redox changes associated with growth factor availability, cell density, mitochondrial depolarization, respiratory burst activity and immune receptor stimulation.

TL;DR: It is shown that the thiol peroxidase peroxiredoxin-2 (Prx2), one of the most H(2)O(2)-reactive proteins in the cell, acts as a H( 2)O (2) signal receptor and transmitter in transcription factor redox regulation.

TL;DR: This work shows in mice that DNA damage is a direct consequence of inducing HSCs to exit their homeostatic quiescent state in response to conditions that model physiological stress, such as infection or chronic blood loss, and provides a mechanistic explanation for the universal accumulation of DNA damage in H SCs during ageing and the accelerated failure of the haematopoietic system in Fanconi anaemia patients.

TL;DR: Genetically encoded redox probes enable the functional analysis of individual proteins in cellular redox homeostasis, and redox biosensor transgenic model organisms offer extended opportunities for dynamic in vivo imaging of redox processes.

TL;DR: These motifs finally explain recent findings describing differential processing of epitopes by constitutive and immunoproteasomes and are important to the understanding of peripheral T cell tolerization/activation as well as for effective vaccine development.