M
Marcus Krantz
Researcher at Humboldt University of Berlin
Publications - 37
Citations - 1343
Marcus Krantz is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Systems biology & Executable. The author has an hindex of 16, co-authored 34 publications receiving 1216 citations. Previous affiliations of Marcus Krantz include Humboldt State University & University of Gothenburg.
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The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes.
TL;DR: In this article, the authors analyzed the transcriptional response to osmotic shock in the yeast Saccharomyces cerevisiae and found that the mRNA level of 186 genes increased at least 3-fold after a shift to NaCl or sorbitol whereas that of more than 100 genes was at least 1.5-fold diminished.
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Comparative genomics of the HOG-signalling system in fungi.
TL;DR: Comparing genomics to analyse the high osmolarity glycerol pathway in fungi found certain proteins proved difficult to identify due to low sequence conservation, and a main limitation was incomplete, low coverage genomic sequences and fragmentary genome annotation.
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A framework for mapping, visualisation and automatic model creation of signal‐transduction networks
Carl Fredrik Tiger,Carl Fredrik Tiger,Falko Krause,Gunnar Cedersund,Gunnar Cedersund,Robert Palmér,Edda Klipp,Stefan Hohmann,Hiroaki Kitano,Marcus Krantz,Marcus Krantz +10 more
TL;DR: A novel framework for mapping signal‐transduction networks that avoids the combinatorial explosion by breaking down the network in reaction and contingency information is presented and provides two new visualisation methods and automatic export to mathematical models.
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Robustness and fragility in the yeast high osmolarity glycerol (HOG) signal‐transduction pathway
Marcus Krantz,Doryaneh Ahmadpour,Lars-Göran Ottosson,Jonas Warringer,Christian Waltermann,Bodil Nordlander,Edda Klipp,Anders Blomberg,Stefan Hohmann,Hiroaki Kitano +9 more
TL;DR: In silico analysis highlights the impact of model structure on in silico robustness, and suggests complex formation and scaffolding as important contributors to the observed fragility patterns, which can be used to discriminate and improve mathematical models.
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Anaerobicity Prepares Saccharomyces cerevisiae Cells for Faster Adaptation to Osmotic Shock
TL;DR: Interestingly, cells adapted to osmotic shock much more rapidly under anaerobiosis, and the signaling as well as the transcriptional response was clearly attenuated under these conditions, due to an enhanced glycerol production capacity in anaerobic cells, which is caused by the need for glycerols production in redox balancing.