M
Marcus M. Seldin
Researcher at University of California, Irvine
Publications - 83
Citations - 5057
Marcus M. Seldin is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 27, co-authored 60 publications receiving 3281 citations. Previous affiliations of Marcus M. Seldin include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Multi-omics approaches to disease.
TL;DR: This review provides an overview of omics technologies and methods for their integration across multiple omics layers and offers the opportunity to understand the flow of information that underlies disease.
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Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
Marcus M. Seldin,Yonghong Meng,Hongxiu Qi,Wei Fei Zhu,Zeneng Wang,Stanley A Hazen,Aldons J. Lusis,Diana M. Shih +7 more
TL;DR: It was shown that activation of nuclear factor‐κB signaling was necessary for TMAO to induce inflammatory gene expression in both of these relevant cell types as well as endothelial cell adhesion of leukocytes, which suggests a likely contributory mechanism for T MAO‐dependent enhancement in atherosclerosis and cardiovascular risks.
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Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis *
TL;DR: The identification and characterization of myonectin are reported, a novel myokine belonging to the C1q/TNF-related protein (CTRP) family, which is a potential nutrient-responsive metabolic regulator secreted by muscle that links skeletal muscle to systemic lipid metabolism via its action on adipocytes and hepatocytes.
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Metabolic function of the CTRP family of hormones
TL;DR: The current understanding of the physiological functions of CTRPs is summarized, emphasizing their metabolic roles, and a highly conserved family of 15 secreted proteins, the C1q/TNF-related proteins (CTRP1-15).
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The Hybrid Mouse Diversity Panel: A Resource for Systems Genetics Analyses of Metabolic and Cardiovascular Traits
Aldons J. Lusis,Marcus M. Seldin,Hooman Allayee,Brian J. Bennett,Mete Civelek,Richard C. Davis,Eleazar Eskin,Charles R. Farber,Simon T. Hui,Margarete Mehrabian,Frode Norheim,Calvin Pan,Brian W. Parks,Christoph Rau,Desmond J. Smith,Thomas Q. de Aguiar Vallim,Yibin Wang,Jessica Wang +17 more
TL;DR: The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits.