M
Marcus Weber
Researcher at Zuse Institute Berlin
Publications - 127
Citations - 3450
Marcus Weber is an academic researcher from Zuse Institute Berlin. The author has contributed to research in topics: Markov chain & Markov process. The author has an hindex of 22, co-authored 121 publications receiving 2944 citations. Previous affiliations of Marcus Weber include Charité.
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Journal ArticleDOI
Multivalency as a chemical organization and action principle.
Carlo Fasting,Christoph A. Schalley,Marcus Weber,Oliver Seitz,Stefan Hecht,Beate Koksch,Jens Dernedde,Christina Graf,Ernst-Walter Knapp,Rainer Haag +9 more
TL;DR: In a systematic review of scaffold architectures, the underlying effects and control options will be demonstrated, and suggestions will be given for designing effective multivalent binding systems, as well as for polyvalent therapeutics.
Journal ArticleDOI
Robust Perron cluster analysis in conformation dynamics
Peter Deuflhard,Marcus Weber +1 more
TL;DR: In this article, an improved Perron cluster analysis algorithm is presented, which is more robust than earlier suggestions, for the detection of metastable conformations in molecular conformation dynamics.
Journal ArticleDOI
Fuzzy spectral clustering by PCCA+: application to Markov state models and data classification
Susanna Röblitz,Marcus Weber +1 more
TL;DR: It is demonstrated in this paper that PCCA+ always delivers an optimal fuzzy clustering for nearly uncoupled, not necessarily reversible, Markov chains with transition states.
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A nontoxic pain killer designed by modeling of pathological receptor conformations
Viola Spahn,G. Del Vecchio,Dominika Labuz,Antonio Rodriguez-Gaztelumendi,Nicolas Massaly,Julia Temp,Vedat Durmaz,P. Sabri,Marco Reidelbach,Halina Machelska,Marcus Weber,Christoph Stein +11 more
TL;DR: A novel opioid receptor agonist that, unlike clinically used opioids, best activates the receptors in such acidified tissues and produced injury-restricted analgesia in rats with different types of inflammatory pain without exhibiting respiratory depression, sedation,constipation, constipation, or addiction potential.
Journal ArticleDOI
Multivalenz als chemisches Organisations- und Wirkprinzip
Carlo Fasting,Christoph A. Schalley,Marcus Weber,Oliver Seitz,Stefan Hecht,Beate Koksch,Jens Dernedde,Christina Graf,Ernst-Walter Knapp,Rainer Haag +9 more
TL;DR: Multivalente Wechselwirkungen konnen universell zur gezielten Bindungsverstarkung zwischen verschiedenen Grenzflachen or Molekulen genutzt werden as mentioned in this paper.