Margaret E. Tome

TL;DR: In this paper, the authors showed that dexamethasone, a synthetic glucocorticoid, causes a down-regulation of several antioxidant defense enzymes and proteins, including catalase and thioredoxin, concomitant with the induction of apoptosis in WEHI7.2 mouse thymoma cells.

TL;DR: Patients with DLBCL with the worst prognosis had decreased expression of catalase, glutathione peroxidase, manganese superoxide dismutase, and VDUP1, a protein that inhibits thioredoxin activity, according to the outcome predictor score.

TL;DR: In this paper, the authors compared denervated and unweighted soleus muscle with chloroquine and methylamine and found that denervation increased the lysosomal proteolysis.

TL;DR: In this article, the authors show that cantharidin (CAN), the active principle ingredient from the blister beetle, Mylabris, has anti-tumor activity, but the cytotoxic mechanism is unknown.

TL;DR: It is reported that imexon has cytotoxic activity in other malignant cell lines including NCI-H929 myeloma cells and NB-4 acute promyelocytic leukemia cells, whereas normal lymphocytes and U266 myELoma cells are substantially less sensitive.