M
Margaret M. Centenera
Researcher at University of Adelaide
Publications - 50
Citations - 2753
Margaret M. Centenera is an academic researcher from University of Adelaide. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 21, co-authored 46 publications receiving 2199 citations. Previous affiliations of Margaret M. Centenera include University of South Australia.
Papers
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Journal ArticleDOI
Dual Roles of PARP-1 Promote Cancer Growth and Progression
Matthew J. Schiewer,Jonathan F. Goodwin,Sumin Han,J. Chad Brenner,Michael A. Augello,Jeffry L. Dean,Fengzhi Liu,Jamie L. Planck,Preethi Ravindranathan,Arul M. Chinnaiyan,Peter McCue,Leonard G. Gomella,Ganesh V. Raj,Adam P. Dicker,Jonathan R. Brody,John M. Pascal,Margaret M. Centenera,Lisa M. Butler,Wayne D. Tilley,Felix Y. Feng,Karen E. Knudsen +20 more
TL;DR: It is suggested that the dual functions of PARP-1 can be targeted in human prostate cancer to suppress tumor growth and progression to castration resistance by modulation of the DNA damage response and hormone signaling pathways.
Journal ArticleDOI
Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer.
Amelia A. Peters,Grant Buchanan,Carmela Ricciardelli,Tina Bianco-Miotto,Margaret M. Centenera,Jonathan M. Harris,Shalini Jindal,Davendra Segara,Li Jia,Nicole L. Moore,Susan M. Henshall,Stephen N. Birrell,Gerhard A. Coetzee,Robert L. Sutherland,Lisa M. Butler,Wayne D. Tilley +15 more
TL;DR: It is concluded that, by binding to a subset of EREs, the AR can prevent activation of target genes that mediate the stimulatory effects of 17beta-estradiol on breast cancer cells.
Androgen receptor inhibits estrogen receptor-A activity and is prognostic in breast cancer
Amelia A. Peters,Grant Buchanan,Carmela Ricciardelli,Tina Bianco-Miotto,Margaret M. Centenera,Jonathan M. Harris,Shalini Jindal,Davendra Segara,Li Jia,Nicole L. Moore,Susan M. Henshall,Stephen N. Birrell,Gerhard A. Coetzee,R. L. Sutherland,Lisa M. Butler,Wayne D. Tilley +15 more
TL;DR: In this paper, the balance between estrogen receptor-α (ERα) and androgen receptor (AR) signaling is a critical determinant of growth in the normal and malignant breast.
Journal ArticleDOI
Maximizing the Therapeutic Potential of Hsp90 Inhibitors
TL;DR: This review considers the recent progress that has been made in the study of HSP90 and its inhibitors and highlights new opportunities to maximize their therapeutic potential.
Journal ArticleDOI
The Contribution of Different Androgen Receptor Domains to Receptor Dimerization and Signaling
TL;DR: Each form of dimerization utilized by the AR to achieve transcriptional competence is discussed and it is highlighted thatDimerization through multiple domains is necessary for optimal AR signaling.