M
Margareta Klein
Researcher at University College London
Publications - 4
Citations - 649
Margareta Klein is an academic researcher from University College London. The author has contributed to research in topics: Cytolysis & Lymphokine-activated killer cell. The author has an hindex of 4, co-authored 4 publications receiving 642 citations. Previous affiliations of Margareta Klein include Queen's University.
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Journal ArticleDOI
A new immunodeficiency disorder in humans involving NK cells.
John C. Roder,John C. Roder,Tina Haliotis,Tina Haliotis,Margareta Klein,Margareta Klein,Stefan Korec,James R. Jett,John R. Ortaldo,Ronald B. Heberman,Paul Katz,Anthony S. Fauci +11 more
TL;DR: It is reported here that patients carrying the analogous, autosomal recessive Chediak-Higashi (CH) gene have a profound defect in their ability to spontaneously lyse various tumour cells in vitro by either antibody-dependent or independent mechanisms.
Journal ArticleDOI
Chediak-Higashi gene in humans. I. Impairment of natural - killer function
Tina Haliotis,John C. Roder,Margareta Klein,John R. Ortaldo,Anthony S. Fauci,Ronald B. Herberman +5 more
TL;DR: Observations suggest that the C-HS gene causes a selective immunodeficiency disorder, mainly involving NK cells, which may have important implications regarding the theory of immune surveillance mediated by NK cells.
Journal Article
Target-effector interaction in the natural killer cell system. IV. Modulation by cyclic nucleotides.
John C. Roder,Margareta Klein +1 more
TL;DR: Results are compatible with the hypothesis that cyclic nucleotides may be involved in triggering the lytic event within NK cells and suggest that the cAMP-cGMP ratio might be important in NK-mediated lysis.
Journal ArticleDOI
Chediak-Higashi gene in humans. II. The selectivity of the defect in natural- killer and antibody-dependent cell-mediated cytotoxicity function
Margareta Klein,John C. Roder,Tina Haliotis,S Korec,Jett,Ronald B. Herberman,P Katz,Anthony S. Fauci +7 more
TL;DR: These results, combined with other studies showing normal cell-mediated and humoral immunity in these same patients, suggest that patients with C-HS have an immunodeficiency which is selective for NK and ADCC activity.