Journal ArticleDOI
A new immunodeficiency disorder in humans involving NK cells.
John C. Roder,John C. Roder,Tina Haliotis,Tina Haliotis,Margareta Klein,Margareta Klein,Stefan Korec,James R. Jett,John R. Ortaldo,Ronald B. Heberman,Paul Katz,Anthony S. Fauci +11 more
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TLDR
It is reported here that patients carrying the analogous, autosomal recessive Chediak-Higashi (CH) gene have a profound defect in their ability to spontaneously lyse various tumour cells in vitro by either antibody-dependent or independent mechanisms.Abstract:
Immunodeficiency disorders have provided much information on the development and interaction of the various B and T lymphoid components in the immune system of man. As the lymphoid system becomes increasingly divided into functional subsets of cells it will be important to find immunodeficiencies affecting newly discovered cell types. Natural killer (NK) cells are a recently described but ill-defined subpopulation of lymphocytes which is thought to play an important part in surveillance against tumour development. Mice homozygous for the beige gene were found to have a selective deficiency in NK function and were more susceptible to transplantation of syngeneic tumours as predicted. We report here that patients carrying the analogous, autosomal recessive Chediak-Higashi (CH) gene have a profound defect in their ability to spontaneously lyse various tumour cells in vitro by either antibody-dependent or independent mechanisms. Since other cell-mediated cytolytic functions were relatively normal, these results suggest that the beige or Chediak-Higashi gene in both man and mouse controls NK function.read more
Citations
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Book ChapterDOI
Biology of natural killer cells.
TL;DR: The existence of NK cells has prompted a reinterpretation of both the studies of specific cytotoxicity against spontaneous human tumors and the theory of immune surveillance, at least in its most restrictive interpretation.
Journal ArticleDOI
Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population
TL;DR: It is indicated that medium and high cytotoxic activity of peripheral-blood lymphocytes is associated with reduced cancer risk, whereas low activity isassociated with increased cancer risk suggesting a role for natural immunological host defence mechanisms against cancer.
Journal ArticleDOI
Biology and clinical relevance of human natural killer cells.
Michael J. Robertson,Jerome Ritz +1 more
TL;DR: Information about subscriptions and ASH membership may be found online at: reserved.org.
Journal ArticleDOI
NK cells and cancer: you can teach innate cells new tricks
Maelig G. Morvan,Lewis L. Lanier +1 more
TL;DR: Evidence for the role of NK cells in immune surveillance against cancer and new therapeutic approaches for targetingNK cells in the treatment of cancer are reviewed.
Journal ArticleDOI
Human natural killer cell deficiencies and susceptibility to infection.
TL;DR: A resounding theme of NK cell deficiencies is susceptibility to herpesviruses, suggesting that unexplained severe herpesviral infection should raise the possibility of an NK cell deficit.
References
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Journal ArticleDOI
Natural Killer Cells: Characteristics and Regulation of Activity
Ronald B. Herberman,Ronald B. Herberman,Ronald B. Herberman,Julie Y. Djeu,Julie Y. Djeu,Julie Y. Djeu,H. David Kay,H. David Kay,H. David Kay,John R. Ortaldo,John R. Ortaldo,John R. Ortaldo,Carlo Riccardi,Carlo Riccardi,Carlo Riccardi,Guy D. Bonnard,Guy D. Bonnard,Guy D. Bonnard,Howard T. Holden,Howard T. Holden,Howard T. Holden,Roberto Fagnani,Roberto Fagnani,Roberto Fagnani,Angela Santoni,Paolo Puccetti,Paolo Puccetti,Paolo Puccetti +27 more
TL;DR: The views on the characteristics of NK cells are summarized and a few issues of current interest in the laboratory are focused on.
Journal ArticleDOI
The beige mutation in the mouse selectively impairs natural killer cell function.
TL;DR: It is reported here that a mutant gene in the mouse called beige (bgJ), leads to a complete and selective impairment of naturally occurring killer lymphocytes, whereas all other forms of cell-mediated lysis are apparently normal.
Journal ArticleDOI
The Chediak-Higashi syndrome: studies in four patients and a review of the literature.
Ralph S. Blume,Sheldon M. Wolff +1 more
Journal ArticleDOI
Abnormal Bactericidal, Metabolic, and Lysosomal Functions of Chediak-Higashi Syndrome Leukocytes
TL;DR: The contrasting patterns and kinetics of the killing defects and the differing metabolic properties of Chediak-Higashi syndrome and chronic granulomatous disease leukocytes emphasize the pleiomorphic nature of inherited disorders of leukocyte function.
Journal ArticleDOI
An analysis of the murine NK cell as to structure, function and biological relevance.
Rolf Kiessling,Hans Wigzell +1 more
TL;DR: The immune system in higher animals has as a major distinguishing feature a high degree of complexity and can be considered to represent the gradual accumulation of preserved experiences during phylogeny where primitive as well as sophisticated reactions occur in parallel during the immune response.