Maria A. Chiacchio

TL;DR: In particular, compounds 7c and 7e show high levels of cytotoxicity on MOLT-3 leukemia cells; 7e exerts a remarkable enhancing activity on apoptosis caused by anti-fas antibody addition.

TL;DR: Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy.

TL;DR: The protective effect of BSext and of the purified products was associated with the inhibition of both HTLV-1 and HIV-1 RT activities in conceptually similar, cell-free assays, showing a favourable selectivity index for the novel BSext product.

TL;DR: The aim of this review is to describe the most recent reports in this field, with reference to the new discovered pyridine- or pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives.

TL;DR: In this paper, seven substituted derivatives of polyhedral oligomeric silsesquioxanes (POSSs) with general formula R7R′1 (SiO1.5)8, where R- and R′- were a cyclopentyl and a substituted phenyl group, respectively, were prepared, and their compositions were checked by elemental analysis, 1H NMR and 13C NMR spectroscopy.