M
Maria A. Chiacchio
Researcher at University of Catania
Publications - 87
Citations - 1118
Maria A. Chiacchio is an academic researcher from University of Catania. The author has contributed to research in topics: Catalysis & Cycloaddition. The author has an hindex of 18, co-authored 82 publications receiving 905 citations.
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Journal ArticleDOI
C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation.
Roberto Romeo,Caterina Carnovale,Salvatore V. Giofrè,Maria A. Chiacchio,Adriana Garozzo,Emanuele Amata,Giovanni Romeo,Ugo Chiacchio +7 more
TL;DR: Biological tests indicate an antitumor activity for the synthesized compounds: most of them inhibit cell proliferation of Vero, BS-C-1, HEp-2, MDCK, and HFF cells with a CC50 in the range of 5.0–40 μM.
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Synthesis and Biological Activity of Triazole-Appended N,O-Nucleosides
Roberto Romeo,Salvatore V. Giofrè,Caterina Carnovale,Maria A. Chiacchio,Agata Campisi,Raffaella Mancuso,Santa Cirmi,Michele Navarra +7 more
TL;DR: 1,2,3-Triazole-appended N,O-nucleosides synthesized by an approach combining a 1-3-dipolar cycloaddition process and an alkyne–azide click chemistry reaction revealed the antiproliferative activity of the synthesized compounds.
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Supramolecular recognition of phosphocholine by an enzyme-like cavitand receptor
Laura Legnani,Roberta Puglisi,Andrea Pappalardo,Maria A. Chiacchio,Giuseppe Trusso Sfrazzetto +4 more
TL;DR: The recognition mechanism proposed here is similar to those exploited by Nature, and paves the way for the realization of new sensors with important applications in medicine and security fields.
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Chiral Synthesis of Carbocyclic Nucleoside Analogs from Noncarbohydrate Precursors
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A new method for the synthesis of carba-sugar enones (gabosines) using a mercury(II)-mediated opening of 4,5-cyclopropanated pyranosides as the key-step ☆
Antonino Corsaro,Venerando Pistarà,Giorgio Catelani,Felicia D'Andrea,R Adamo,Maria A. Chiacchio +5 more
TL;DR: In this article, the Simmons-Smith reaction was used to transform cyclopropyl derivatives into gabosines and deoxy-carbahexoses, which were then catalytically reduced to carba-sugars.