M
Maria A. Chiacchio
Researcher at University of Catania
Publications - 87
Citations - 1118
Maria A. Chiacchio is an academic researcher from University of Catania. The author has contributed to research in topics: Catalysis & Cycloaddition. The author has an hindex of 18, co-authored 82 publications receiving 905 citations.
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Journal ArticleDOI
Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
Antonio Rescifina,Maria A. Chiacchio,Antonino Corsaro,Erik De Clercq,Daniela Iannazzo,Antonio Mastino,Anna Piperno,Giovanni Romeo,Roberto Romeo,Vincenza Valveri +9 more
TL;DR: In particular, compounds 7c and 7e show high levels of cytotoxicity on MOLT-3 leukemia cells; 7e exerts a remarkable enhancing activity on apoptosis caused by anti-fas antibody addition.
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Synthesis and biological activity of phosphonated nucleosides: part 1. Furanose, carbocyclic and heterocyclic analogues.
TL;DR: Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy.
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Antiviral activity of seed extract from Citrus bergamia towards human retroviruses
Emanuela Balestrieri,Francesco Pizzimenti,Angelo Ferlazzo,Salvatore V. Giofrè,Daniela Iannazzo,Anna Piperno,Roberto Romeo,Maria A. Chiacchio,Antonio Mastino,Beatrice Macchi +9 more
TL;DR: The protective effect of BSext and of the purified products was associated with the inhibition of both HTLV-1 and HIV-1 RT activities in conceptually similar, cell-free assays, showing a favourable selectivity index for the novel BSext product.
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Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents
TL;DR: The aim of this review is to describe the most recent reports in this field, with reference to the new discovered pyridine- or pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives.
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Thermal degradation of differently substituted Cyclopentyl Polyhedral Oligomeric Silsesquioxane (CP-POSS) nanoparticles
TL;DR: In this paper, seven substituted derivatives of polyhedral oligomeric silsesquioxanes (POSSs) with general formula R7R′1 (SiO1.5)8, where R- and R′- were a cyclopentyl and a substituted phenyl group, respectively, were prepared, and their compositions were checked by elemental analysis, 1H NMR and 13C NMR spectroscopy.