M
María C. García
Researcher at GlaxoSmithKline
Publications - 3
Citations - 44
María C. García is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Bioavailability & Scale (ratio). The author has an hindex of 2, co-authored 3 publications receiving 38 citations.
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Journal ArticleDOI
Potent antimalarial 4-pyridones with improved physico-chemical properties
Jose M. Bueno,Pilar Manzano,María C. García,Jesús Chicharro,Margarita Puente,Milagros Lorenzo,Adolfo García,Santiago Ferrer,Rubén M. Gómez,María T. Fraile,Jose Luis Lavandera,Jose M. Fiandor,J. Vidal,Esperanza Herreros,Domingo Gargallo-Viola +14 more
TL;DR: The strategy of introducing polar hydroxymethyl groups has enabled us to maintain the high levels of antimalarial potency observed for other more lipophilic analogues whilst improving the solubility and the oral bioavailability in pre-clinical species.
Journal ArticleDOI
Use of Lithium Diisopropylamide in Flow: Operability and Safety Challenges Encountered on a Multigram Scale
Marta León Alonso,María C. García,Christopher McKay,Lee R. Thorp,Michael R. Webb,Lee Edwards +5 more
TL;DR: A workflow for the development of organometallic processes in flow was applied to synthesize 1-(5-bromopyridin-2-yl)-2-methylpropan-2ol, a pharmaceutical intermediate as mentioned in this paper.
Journal ArticleDOI
Corrigendum to “Potent antimalarial 4-pyridones with improved physico-chemical properties” [Bioorg. Med. Chem. Lett. 21 (2011) 5214–5218]
Jose M. Bueno,Pilar Manzano,María C. García,Jesús Chicharro,Margarita Puente,Milagros Lorenzo,Adolfo García,Santiago Ferrer,Rubén M. Gómez,María T. Fraile,Jose Luis Lavandera,Jose M. Fiandor,J. Vidal,Esperanza Herreros,Domingo Gargallo-Viola +14 more