Maria Cristina Gagliani

TL;DR: VEC limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments, and silencing the junction-associated density-enhanced phosphatase-1/CD148 phosph atase restores VEGfr-2 internalization and signaling.

TL;DR: Real-time monitoring of G-protein-coupled receptor (GPCR) signaling in native cells suggests that the receptor for thyroid stimulating hormone remains active after internalization, challenging the current model for GPCR signaling.

TL;DR: It is demonstrated that Numb is an endocytic protein that localizes toendocytic organelles and is cotrafficked with internalizing receptors, and fragments of Numb act as dominant negatives on both constitutive and ligand-regulated receptor-mediated internalization, suggesting a general role for Numb in the Endocytic process.

TL;DR: It is proposed that DRM-associated endocytosis allows efficient retrieval of integrins, as they detach from their ligands, followed by polarized recycling to areas of the plasma membrane, such as lamellipodia, where they establish new adhesive interactions and promote outside-in signaling events.

TL;DR: Nematode genetics allowed not only the unmasking of distinct EPS-8-linked phenotypes, but also the definition of a novel function for this molecule in actin dynamics.