C
Carlo Tacchetti
Researcher at Vita-Salute San Raffaele University
Publications - 145
Citations - 10649
Carlo Tacchetti is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Internalization & Endosome. The author has an hindex of 52, co-authored 135 publications receiving 9652 citations. Previous affiliations of Carlo Tacchetti include University of Genoa & Laboratory of Molecular Biology.
Papers
More filters
Journal ArticleDOI
Clathrin-independent endocytosis of ubiquitinated cargos
Sara Sigismund,Tanja Woelk,Claudia Puri,Elena Maspero,Carlo Tacchetti,Pietro Transidico,Pier Paolo Di Fiore,Simona Polo +7 more
TL;DR: It is shown that the epidermal growth factor (EGF) receptor (EGFR), when stimulated with low doses of EGF, is internalized almost exclusively through the clathrin pathway, and it is not ubiquitinated.
Journal ArticleDOI
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments.
Maria Grazia Lampugnani,Fabrizio Orsenigo,Maria Cristina Gagliani,Carlo Tacchetti,Elisabetta Dejana,Elisabetta Dejana +5 more
TL;DR: VEC limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments, and silencing the junction-associated density-enhanced phosphatase-1/CD148 phosph atase restores VEGfr-2 internalization and signaling.
Journal ArticleDOI
A block of autophagy in lysosomal storage disorders
Carmine Settembre,Alessandro Fraldi,Luca Jahreiss,Carmine Spampanato,Consuelo Venturi,Diego L. Medina,Raquel de Pablo,Carlo Tacchetti,David C. Rubinsztein,Andrea Ballabio +9 more
TL;DR: Lysosomal storage impairs autophagic delivery of bulk cytosolic contents to lysosomes, identifying LSDs as 'autophagy disorders' and suggesting the presence of common mechanisms in the pathogenesis of these and other neurodegenerative diseases.
Journal ArticleDOI
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.
Davide Calebiro,Viacheslav O. Nikolaev,Maria Cristina Gagliani,Tiziana de Filippis,Christian Dees,Carlo Tacchetti,Luca Persani,Martin J. Lohse +7 more
TL;DR: Real-time monitoring of G-protein-coupled receptor (GPCR) signaling in native cells suggests that the receptor for thyroid stimulating hormone remains active after internalization, challenging the current model for GPCR signaling.
Journal ArticleDOI
Integrin-induced Epidermal Growth Factor (EGF) Receptor Activation Requires c-Src and p130Cas and Leads to Phosphorylation of Specific EGF Receptor Tyrosines
Laura Moro,Laura Dolce,Sara Cabodi,Elena Bergatto,Elisabetta Boeri Erba,Monica Smeriglio,Emilia Turco,Saverio Francesco Retta,Maria Gabriella Giuffrida,Mascia Venturino,Jasminka Godovac-Zimmermann,Amedeo Conti,Erik Schaefer,Laura Beguinot,Carlo Tacchetti,Paolo Gaggini,Lorenzo Silengo,Guido Tarone,Paola Defilippi +18 more
TL;DR: Data indicate that integrin-mediated adhesion induces assembly of a macromolecular complex containing c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosine residues.