M
Maria Densmore
Researcher at Lawson Health Research Institute
Publications - 17
Citations - 1202
Maria Densmore is an academic researcher from Lawson Health Research Institute. The author has contributed to research in topics: Resting state fMRI & Default mode network. The author has an hindex of 11, co-authored 17 publications receiving 920 citations.
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Journal ArticleDOI
Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: Decreased connectivity with caudate nucleus
Robyn Bluhm,Peter C. Williamson,Ruth A. Lanius,Jean Théberge,Maria Densmore,Robert Bartha,Richard W. J. Neufeld,Elizabeth A. Osuch +7 more
TL;DR: The DMN is investigated in patients seeking help from specialized mental health services for the first time for symptoms of depression in relatively early depression before years of medication treatment.
Journal ArticleDOI
The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback.
Andrew A. Nicholson,Daniela Rabellino,Maria Densmore,Paul A. Frewen,Christian Paret,Rosemarie Kluetsch,Christian Schmahl,Jean Théberge,Richard W. J. Neufeld,Margaret C. McKinnon,Jeffrey P. Reiss,Rakesh Jetly,Ruth A. Lanius +12 more
TL;DR: This is the first demonstration of successful downregulation of the amygdala using rt‐fMRI‐nf in PTSD, which was critically sustained in a subsequent transfer run without neurofeedback, and corresponded to increased connectivity with prefrontal regions involved in emotion regulation during the intervention.
Journal ArticleDOI
The Dissociative Subtype of Posttraumatic Stress Disorder: Unique Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes
Andrew A. Nicholson,Maria Densmore,Paul A. Frewen,Jean Théberge,Richard W. J. Neufeld,Margaret C. McKinnon,Ruth A. Lanius +6 more
TL;DR: Differences in amygdala complex connectivity to specific brain regions parallel the unique symptom profiles of the PTSD subgroups and point towards unique biological markers of the dissociative subtype of PTSD.
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Dynamic causal modeling in PTSD and its dissociative subtype: Bottom-up versus top-down processing within fear and emotion regulation circuitry.
Andrew A. Nicholson,Andrew A. Nicholson,Karl J. Friston,Peter Zeidman,Sherain Harricharan,Sherain Harricharan,Margaret C. McKinnon,Margaret C. McKinnon,Margaret C. McKinnon,Maria Densmore,Richard W. J. Neufeld,Jean Théberge,Frank Corrigan,Rakesh Jetly,David Spiegel,Ruth A. Lanius,Ruth A. Lanius +16 more
TL;DR: The contrasting symptom profiles of PTSD and its dissociative subtype may be driven by complementary changes in directed connectivity corresponding to bottom–up defensive fear processing versus enhanced top–down regulation.
Journal ArticleDOI
Unique insula subregion resting-state functional connectivity with amygdala complexes in posttraumatic stress disorder and its dissociative subtype
Andrew A. Nicholson,Iman S Sapru,Maria Densmore,Paul A. Frewen,Richard W. J. Neufeld,Jean Théberge,Margaret C. McKinnon,Ruth A. Lanius,Ruth A. Lanius +8 more
TL;DR: This study is an important first step in elucidating patterns of neural connectivity associated with unique symptoms of arousal/interoception, emotional processing, and awareness of bodily states, in PTSD and its dissociative subtype.