M
Maria E. Piccone
Researcher at United States Department of Agriculture
Publications - 18
Citations - 1279
Maria E. Piccone is an academic researcher from United States Department of Agriculture. The author has contributed to research in topics: Virus & Foot-and-mouth disease virus. The author has an hindex of 13, co-authored 18 publications receiving 1186 citations. Previous affiliations of Maria E. Piccone include University of Connecticut.
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Journal ArticleDOI
Genomes of the Parapoxviruses Orf Virus and Bovine Papular Stomatitis Virus
G. Delhon,G. Delhon,Edan R. Tulman,Claudio L. Afonso,Z. Lu,A. de la Concha-Bermejillo,Howard D. Lehmkuhl,Maria E. Piccone,Gerald F. Kutish,Daniel L. Rock +9 more
TL;DR: Compared to other mammalian chordopoxviruses, PPV shares unique genomic features with molluscum contagiosum virus, including a G+C-rich nucleotide composition, three orthologous genes, and a paucity of nucleotide metabolism genes.
Journal ArticleDOI
African Swine Fever Virus Multigene Family 360 and 530 Genes Affect Host Interferon Response
Claudio L. Afonso,Maria E. Piccone,K. M. Zaffuto,J. G. Neilan,Gerald F. Kutish,Z. Lu,C. A. Balinsky,T. R. Gibb,T. J. Bean,Laszlo Zsak,Daniel L. Rock +10 more
TL;DR: The absence of IFN-α in Pr4-infected macrophages suggests that MGF360/530 genes either directly or indirectly suppress a type IIFN response, and an inability to suppress host type I IFN responses may account for the growth defect of Pr4Δ35 in Macrophages and its attenuation in swine.
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Ability of Foot-and-Mouth Disease Virus To Form Plaques in Cell Culture Is Associated with Suppression of Alpha/Beta Interferon
TL;DR: The results obtained with cell cultures demonstrate that the ability of A12-IC to form plaques is associated with the suppression of IFN-α/β expression and suggest a role for this host factor in the inability of A 12-LLV2 to spread and cause disease in susceptible animals.
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The foot-and-mouth disease virus leader proteinase gene is not required for viral replication.
TL;DR: These studies indicate that the L proteinase is not essential for FMDV replication and show that in the cells and animals tested the L gene has a limited effect on virus replication.
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Evaluation of a live-attenuated foot-and-mouth disease virus as a vaccine candidate.
TL;DR: The potential of a rationally designed live-attenuated FMDV vaccine is demonstrated by animals vaccinated with inactivated virus, which showed no clinical signs of disease and developed a neutralizing antibody response, and the control did not seroconvert.