M
Maria Gomez-Lazaro
Researcher at University of Porto
Publications - 40
Citations - 1404
Maria Gomez-Lazaro is an academic researcher from University of Porto. The author has contributed to research in topics: Mitochondrion & Mitochondrial permeability transition pore. The author has an hindex of 19, co-authored 37 publications receiving 1192 citations. Previous affiliations of Maria Gomez-Lazaro include University of Marburg & University of Castilla–La Mancha.
Papers
More filters
Journal ArticleDOI
6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells
Maria Gomez-Lazaro,Nina A. Bonekamp,Maria F. Galindo,Maria F. Galindo,Joaquín Jordán,Michael Schrader +5 more
TL;DR: Biochemical experiments revealed that 6-OHDA-induced mitochondrial fragmentation is an early event preceding the collapse of the mitochondrial membrane potential and cytochrome c release in SH-SY5Y cells, and demonstrated for the first time an involvement of mitochondrial fragmentation and Drp1 function in 6-ohda-induced apoptosis.
Journal ArticleDOI
Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase Activate Bax to Induce Mitochondrial Cytochrome c Release and Apoptosis in Response to Malonate
Maria Gomez-Lazaro,Maria F. Galindo,R. M. Melero-Fernandez de Mera,F.J. Fernandez-Gomez,Caoimhín G. Concannon,Miguel F. Segura,Joan X. Comella,Jochen H. M. Prehn,Joaquín Jordán +8 more
TL;DR: The data suggest that malonate-induced ROS production and subsequent p38 MAP kinase activation mediates the activation of the pro-apoptotic Bax protein to induce mitochondrial membrane permeabilization and neuronal apoptosis.
Journal ArticleDOI
6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.
Maria Gomez-Lazaro,Maria F. Galindo,Caoimhín G. Concannon,Miguel F. Segura,F.J. Fernandez-Gomez,Nuria Llecha,Joan X. Comella,Jochen H. M. Prehn,Joaquín Jordán +8 more
TL;DR: In this article, the authors studied the mechanism of increased mitochondrial membrane permeability of SH-SY5Y neuroblastoma cells in response to 6-hydroxydopamine (6-OHDA).
Journal ArticleDOI
p53: twenty five years understanding the mechanism of genome protection.
TL;DR: The p53 protein turns twenty five years old in 2017 as mentioned in this paper and is considered a pharmacological target, p53 overexpression induces apoptosis in cancer and its expression blockage protects cells against lethal insults.
Journal ArticleDOI
Biological Implications of Differential Expression of Mitochondrial-Shaping Proteins in Parkinson's Disease.
TL;DR: With the bioinformatics approach using the data on the modified proteins in Parkinson’s disease patients, the alteration of mitochondrial-shaping proteins to modifications of crucial cellular pathways affected in this disease are related.