M
Maria Grazia Spillantini
Researcher at University of Cambridge
Publications - 258
Citations - 46057
Maria Grazia Spillantini is an academic researcher from University of Cambridge. The author has contributed to research in topics: Tau protein & Frontotemporal dementia. The author has an hindex of 89, co-authored 247 publications receiving 41532 citations. Previous affiliations of Maria Grazia Spillantini include Medical Research Council & Queen Mary University of London.
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Journal ArticleDOI
Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
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α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
TL;DR: It is shown thatLewy bodies and Lewy neurites from Parkinson’s disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of α-synuclein, showing the presence of full- length or close to full-length α- synuclein.
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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
TL;DR: Antisera raised against synthetic peptides corresponding to these different human tau isoforms demonstrate that multiple tau protein isoforms are incorporated into the neurofibrillary tangles of Alzheimer's disease.
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A Century of Alzheimer's Disease
TL;DR: The ongoing molecular dissection of the neurodegenerative pathways is expected to lead to a true understanding of disease pathogenesis.
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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
Maria Grazia Spillantini,Jill R. Murrell,Michel Goedert,Martin R. Farlow,Aaron Klug,Bernardino Ghetti +5 more
TL;DR: The results show that dysregulation of tau protein production can cause neurodegeneration and imply that the FTDP-17 gene is the tau gene, which has major implications for Alzheimer's disease and other tauopathies.