M
Maria Helkkula
Researcher at University of Turku
Publications - 1
Citations - 13
Maria Helkkula is an academic researcher from University of Turku. The author has contributed to research in topics: Receptor tyrosine kinase & Phosphorylation. The author has an hindex of 1, co-authored 1 publications receiving 9 citations.
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SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase
Anna M. Knittle,Maria Helkkula,Mark S. Johnson,Maria Sundvall,Maria Sundvall,Klaus Elenius,Klaus Elenius +6 more
TL;DR: It is reported that the conserved lysine residue 714 in the ErbB4 ICD undergoes SUMO modification, which was reversed by sentrin-specific proteases (SENPs) 1, 2, and 5, and indicates that a SUMOylation-mediated mechanism regulates nuclear localization and function of the ICD of Erb B4 receptor tyrosine kinase.