M
María J. Romero
Researcher at University of Warwick
Publications - 7
Citations - 238
María J. Romero is an academic researcher from University of Warwick. The author has contributed to research in topics: Irradiation & Chirality (chemistry). The author has an hindex of 5, co-authored 7 publications receiving 200 citations. Previous affiliations of María J. Romero include University of Santiago de Compostela.
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Journal ArticleDOI
The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(II) arene anticancer complexes
Ying Fu,María J. Romero,Abraha Habtemariam,Michael E. Snowden,Lijiang Song,Guy J. Clarkson,Bushra Qamar,Ana M. Pizarro,Patrick R. Unwin,Peter J. Sadler +9 more
TL;DR: In this paper, the chemical reactivity and anticancer activity of organometallic OsII complexes [Os(η6-arene)(XY)Z]PF6 where arene = p-cymene or biphenyl, XY = N,N′-chelated phenyliminopyridine or phenylazopiridine derivatives, and Z = Cl or I.
Journal ArticleDOI
Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes.
Rebecca Carter,A Westhorpe,María J. Romero,María J. Romero,Abraha Habtemariam,CR Gallevo,Y Bark,N Menezes,Peter J. Sadler,Ricky A. Sharma +9 more
TL;DR: The postulated that ruthenium-arene complexes are radiosensitisers when used in combination with RT is postulated, widening the potential scope for these drugs for use in cancer therapy, including combination with radiotherapy to treat colorectal cancer.
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Mirror‐Image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity
Ying Fu,Rina Soni,María J. Romero,Ana M. Pizarro,Luca Salassa,Guy J. Clarkson,Jessica M. Hearn,Abraha Habtemariam,Martin Wills,Peter J. Sadler +9 more
TL;DR: It is shown that the two potent iodido complexes, 2 and 4, share surprisingly similar cancer cell selectivity patterns with the anti-microtubule drug, vinblastine sulfate, an observation that appears to indicate a novel mechanism of action.
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The potent anti-cancer activity of Dioclea lasiocarpa lectin
Ana C. S. Gondim,Isolda Romero-Canelón,Eduardo H.S. Sousa,Claudia A. Blindauer,Jennifer S. Butler,María J. Romero,Carlos Sanchez-Cano,Bruno Lopes de Sousa,Renata Pinheiro Chaves,Celso Shiniti Nagano,Benildo Sousa Cavada,Peter J. Sadler +11 more
TL;DR: Interestingly, DLasiL lectin caused a G2/M arrest in A2780 cells after 24h exposure, activating caspase 9 and delaying the on-set of apoptosis, and it is suggested that further investigations to explore the potential ofDLasiL as a new anticancer agent are warranted.
Journal ArticleDOI
Os2–Os4 Switch Controls DNA Knotting and Anticancer Activity
Ying Fu,Ying Fu,María J. Romero,María J. Romero,Luca Salassa,Xi Quan Cheng,Abraha Habtemariam,Guy J. Clarkson,Ivan Prokes,Alison Rodger,Giovanni Costantini,Peter J. Sadler +11 more
TL;DR: It is shown here that linking dihydroxido‐bridged OsII–arene fragments by a bridging di‐imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA.