Maria Maryanovich

TL;DR: Studying mouse models of prostate cancer, it is shown that endothelial β-adrenergic receptor signaling via adrenergic nerve–derived noradrenaline in the prostate stroma is critical for activation of an angiogenic switch that fuels exponential tumor growth.

TL;DR: It is shown that HSC aging critically depends on bone marrow innervation by the sympathetic nervous system (SNS), as loss of SNS nerves or adrenoreceptor β3 signaling in the bone marrow microenvironment of young mice led to premature HSC Aging, as evidenced by appearance of HSC phenotypes reminiscent of physiological aging.

TL;DR: The importance of neural signaling in hematopoietic homeostasis, inflammation, and cancer is reviewed and the need to redesign therapeutic strategies to target this underappreciated stromal constituent is outlined.

TL;DR: Five transcriptional regulators are identified that can revitalize Nestin-expressing mesenchymal stromal cells to enhance the synthesis of haematopoietic stem cell niche factors, improve haemorrhaging stem cell expansion and protect them against DNA damage.

TL;DR: The interplay of the nervous system with bone, BM, and immunity is reviewed, and future challenges to target hematological diseases through modulation of activity ofThe nervous system are discussed.