Maria Pia Arrate

TL;DR: VU661013 is described, a novel, potent, selective MCL1 inhibitor that destabilizes BIM/MCL1 association, leads to apoptosis in AML, and is active in venetoclax-resistant cells and patient-derived xenografts.

TL;DR: It is determined that miR-31 is overexpressed in human lung adenocarcinoma and this overexpression independently correlates with decreased patient survival and is distinguished as a driver of lung tumorigenesis that promotes mutant KRAS-mediated oncogenesis and reveals that mi R-31 directly targets and reduces expression of negative regulators of RAS/MAPK signaling.

TL;DR: It is reported that a haploinsufficiency of Dicer in B cells failed to promote B-cell malignancy or accelerate Myc-induced B- cell lymphomagenesis in mice, and Dicer ablation was strongly selected against during Myc's B-cells lymphoma development.

TL;DR: It is demonstrated that NF-κB and MAPK pathways are largely unaffected in primary cells from mice harboring a ubiquitination-defective form of NEMO, NemO-KR, which is more resistant to LPS-induced endotoxic shock than wild-type animals.

TL;DR: A novel p53- and Mdm2-independent oncogenic function of Mdmx is revealed that provides new insight into the many cancers that overexpress MDMx and resulted in delayed DNA repair and increased genome instability and transformation independent of p53 and MDM2.