Maria Pytel

TL;DR: It is indicated that desensitization rate is the fastest ligand-independent transition in the GABAAR gating scheme, and the pH dependencies of amplitudes were almost opposite, which resulted from a much shorter receptor exposure to agonist in the case of mIPSCs.

TL;DR: 17β‐Estradiol and related compounds may be neuroprotective agents suitable for use in critically ill infants and toddlers and its supplementation may particularly help to improve neurocognitive outcome in preterm infants who are prematurely deprived of maternal estrogen.

TL;DR: The present data indicate that memantine attenuates the toxic effects of various proapoptotic agents and the cytoprotective effect of memantine does not seem to be connected with its action on NMDA receptor but rather with its influence on intracellular pathways engaged in cellular survival/apoptosis processes.

TL;DR: The present study investigates the effects of beta cyclodextrin (βCD) on GABAA receptor (GABAAR) gating and concludes that βCD is a strong modulator of GABAAR conformational transitions.

TL;DR: Evidence is provided that extracellular protons strongly affect GABAA receptors and that, depending on the presence of the γ2 subunit, the modulatory mechanisms show profound quantitative and qualitative differences.